摘要
于固─液相转移催化条件下，以PEG─400为催化剂，通过对氯苯酚与氯乙酸乙酯反应合成了对氯苯氧基乙酸乙酯（Ⅰ）．（Ⅰ）与85％的NH2NH2·H2O作用便得相应的酰肼（Ⅱ）．（Ⅱ）分别与乙酰雨酮和乙酰乙酸乙酯反应，便得到1-对氯苯氧基乙酰基-3，5-二甲基吡唑（Ⅲ）和1-对氯苯氧基乙酰基-3-甲基吡唑啉-5-酮（Ⅳ）．
In this paper ethyl p -chloro phenoxyacetate(Ⅰ) has been synthesised by the reaction of p -chlorophonol with ethyl chloroacetate under the condition of Solid-Liquid phase transfer catalysis using PEG -400 as the catalyst. (Ⅰ) reacts with 85% hydrazine hydrate to give the corresponding acyl hydrazide(Ⅱ), (Ⅱ) reacts with acetylacetone or ethyl acetoacetate to yield 1-p- chloro phenoxyacetyl -3,5-dimethyl pyrazole (Ⅲ)and 1 -p -chloro phenoxy -acetyl -3-methyl pyrazolin-5-one(Ⅳ),respectivily.
出处
《甘肃教育学院学报（自然科学版）》
1998年第2期48-52,共5页
Journal of Gansu Education College(Natural Science Edition)
关键词
对氯苯氧基
乙酰基
二甲基吡唑
合成
生物活性
1-p-chloro phenoxyacetyl-3, 5-dimethyl pyrazole 1-p-chloro phenoxyacetyl-3-methyl pyrazolin-5-5-one synthesis
