摘要
目的:调查我院门诊功能性消化不良(FD))患者的抑郁症,为心理治疗FD提供依据。方法:以DSM-Ⅳ为标准诊断抑郁症,Zung抑郁自评量表评价其严重程度。将伴抑郁的FD分为3组:对照(常规内科治疗)、氟西汀、多虑平组,随访12周,以FD症状计分及Zung积分减少50％或以上为治疗有效。结果:1.158例FD中43例诊断为抑郁症,其发生率为27.22％,2.氟西汀和多虑平治疗的有效率分别为78.5％(11/14)和72.33％(8/11),其FD症状分和Zung积分明显下降,与对照有显著性差异(P<0.001。结论:FD伴随的抑郁症发生率高,抗抑郁治疗能有效地改善抑郁和消化不良症状,治疗首选SSRIs。
Objective: To determine the prevalence of depression in the patients with functional dyspepsia(FD). Clinical trial was conducted to compare the efficacy and the adverse reactions between fluoxetine, doxepine and control.Methods:Depression was diagnosed according to DSM-TV criteria and the severity of depressive symptoms was evaluated with the Zung Depression Scale. Fluoxetine was given 20～40mg/d and doxepine began with.the initial dose of 25mg/d and doses were increased up to 150mg/d.The patients were followed-up for 12 weeks.Results: 1.The prevalence of depression was 27.22％(43/158)in FD Pafients;2.The mean Zung scores and FD scores were significantly improved after the treatment in both fluoxetine and doxepine(P<0.001 vs.control)and no significant differences were found between the two groups(P>0.05), 3. The frequency of adverse reactions in the fluoxetine group(40％)was significantly lower than that in doxepine (nearly 100％), (P<0.001). Conclusion: The prevalence of depression is high in FD patients and antidepressants improve the depressive and dyspeptic symptoms effectively.
