摘要
目的:观察八味通络颗粒联合常规西药治疗扩张型心肌病的安全性及对血浆脑利钠肽(BNP)的影响。方法:选择60例扩张型心肌病患者,随机分为两组(各30例),治疗组予常规西药加中药制剂八味通络颗粒,对照组使用常规西药加八味通络颗粒模拟剂。疗程均为8周。观察治疗前后LVEDV、LVESV、LVEF、FS、E/A及血浆脑利钠肽(BNP)的变化情况。结果:血浆脑利钠肽水平随心功能的加重而升高,且在Ⅱ级与Ⅲ级、Ⅱ级与Ⅳ级之间有显著性差异(P<0.01),血浆脑利钠肽治疗组较对照组疗后无显著性差异,但组内较疗前均有很大改善。结论:八味通络颗粒联合西药较单纯西药治疗扩张型心肌病能够起到增效减毒的作用,改善心功能,缓解症状,未见不良反应。
Objective： To observe the clinical efficacy and safety of Granule of Eight Herbs for Clearing out Collaterals combined with conventional western medicine on dilated cardiomyopathy and brain natriuretie peptide （BNP） in plasma. Method： 60 cases with dilated cardiomyopathy were randomly divided into treatment group （30 eases） and control group （30 cases）. The cases in treatment group were treated with conventional western medicine and Granule of Eight Herbs for Clearing out Collaterals, and the ones in control group were done with conventional western medicine and simulation of Granule of Eight Herbs for Clearing out Collaterals. A course of treatment included 8 weeks. Observe the clinical symptoms, cardiac functional grading, LVEDV, LVESV, LVEF, FS, E/A and BNP before and after treatment. Result： BNP levels increased along with the aggravated cardiac function, and there were significant differences between grade Ⅱand grade Ⅲ, and grade Ⅱand grade IV （ P 〈 0.01 ）. There was no significant difference on BNP between treatment group and control group after the treatment, but BNP was improved greatly in the groups compared with before treatment. Conclusion ： Granule of Eight Herbs for Clearing out Collaterals combined with western medicine can improve cardiac function, strengthen the efficacy and lessen toxic reaction. It can relieve painful symptoms without any adverse reactions.
出处
《山西中医》
2010年第4期44-46,共3页
Shanxi Journal of Traditional Chinese Medicine
