摘要
组蛋白去乙酰化酶6(HDAC6)是位于胞浆中的一种去乙酰化酶,参与调控细胞内多种重要的生物活性,可使α-微管蛋白(α-tubulin)、热休克蛋白90(Hsp90)和皮肌动蛋白(cortactin)去乙酰化,并与多种蛋白质缔结形成复合物。在细胞培养中,当产生的错误折叠蛋白超过了分子伴侣再折叠及泛素蛋白酶体系统(UPS)处理能力时,HDAC6可将其特异转运到细胞核周结构——异常蛋白包涵体(aggresome)中,从而使之被自噬有效降解,因此认为HDAC6在异常蛋白降解中发挥了关键的调控功能,是"蛋白构象病"的潜在治疗靶点。
Histone deacetylase 6 （HDAC6） is a cytoplasmic enzyme that regulates many important biological processes. It deacetylates α-tubulin, Hsp90 and cortactin, and forms complexes with other partner proteins. When the misfolded proteins are too more to be degradated by the chaperone refolding system and the ubiquitin-proteasome system in cultured cells, misfolded proteins are specifically transported to a cytoplasmic juxtanuclear structure called aggresome by HDAC6, facilitating their clearance by autophagy. The diverse functions of HDAC6 in misfolded proteins degradation pathway suggest that it is a potential therapeutic target for the treatment of ＂conformational diseases＂.
出处
《生理科学进展》
CAS
CSCD
北大核心
2010年第2期112-116,共5页
Progress in Physiological Sciences
基金
国家自然科学基金资助课题(30870869)
