摘要
目的观察左卡尼丁联用促红细胞生成素(EPO)对维持性血液透析患者肾性贫血的疗效及EPO用量的影响。方法采用同期随机对照研究,选择2009年3-9月于我院血液净化中心行维持性血液透析的患者共36例,随机分为3组,常规剂量EPO治疗组(A组)12例、小剂量EPO加左卡尼丁治疗组(B组)13例及常规剂量EPO加左卡尼丁治疗组(C组)11例,观察各组方法治疗8周后贫血指标的变化。结果治疗后第4周,各组血红蛋白(Hb)和红细胞压积(Hct)水平均较治疗前升高,但各组之间比较差异无统计学意义(P>0.05);治疗第8周时,各组患者Hb、Hct水平明显上升(P<0.01),但C组患者Hb、Hct高于A、B组(P<0.05);B组患者EPO用量较A组少,但B组患者Hb、Hct水平高于A组,两组比较差异有统计学意义(P<0.05)。结论左卡尼丁与EPO联用可提高治疗维持性血液透析患者肾性贫血的疗效,纠正贫血,减少EPO的用量。
Objective To analyze the effects of L-carnitine combined with erythropoietin on patients treated with maintenance hemodialysis and assess whether combined therapy could decrease the requirement for exogenous erythropoietin.Methods Thirty-six patients were randomly divided into three groups：12 patients were treated with regular dose EPO（Group A）,13 patients were treated with less dose EPO and L-carnitine（Group B）,11 patients were treated with regular dose EPO and L-carnitine（Group C）.All patients were treated for 8 weeks.Then the results of anemia treatment were compared in three groups of patients.Results The improvement of blood morphology parameters（Hb and Hct）were observed in each group after 4 weeks treatment.After 8 weeks treatment,significant improvement appeared（P0.01）and the increments of Hb and Hct in Group C were more than those in Group B and Group A（P0.05）.Though less EPO was used in Group B,the increments of Hb and Hct in Group B were more than those in Group A（P0.05）.Conclusion L-carnitine combined with erythropoietin can improve the curative effect of renal anemia in maintenance hemodialysis patients,and can decrease the requirement for exogenous erythropoietin.
出处
《实用药物与临床》
CAS
2010年第2期113-114,共2页
Practical Pharmacy and Clinical Remedies
