摘要
目的：评价鲨鱼软骨提取物（SCAE）对C57BL／6J小鼠B16黑色素瘤肺转移的影响。方法：小鼠经尾静脉接种B16黑色素瘤细胞悬液（5×104／每鼠）后d21，观察SCAE低、中、高剂量及环磷酰胺、生理盐水对照组小鼠肺部转移瘤生长情况。结果：SCAE及环磷酰胺对C57BL／6J小鼠经血道B16黑色素瘤肺转移均有明显的抑制作用，其肺校重及肺转移灶数均低于对照组，但后者主要免疫器官胸腺呈现明显萎缩，而SCAE各剂量组无此毒副作用。
Aim: it was evaluted that shark eartilage activated extract(SCAE) influence upon the lung metastasis of B16 melanoma in C57BL/6J mice.Method:the situation of lung metastasis was observed in groups after intravenous injection of B16 melanoma cell d21. Results: SCAE and cytoxan (CTX) could significantly inhibited the pulmonary metastasis of B16 melanoma in the mice. Their lung weight index and number of lung metastasis node were much lower than that of the control group. The thymus gland of CTX group was atrophied significantly, but yet the SCAE and the control did not.
出处
《中国生化药物杂志》
CAS
CSCD
1998年第6期378-380,共3页
Chinese Journal of Biochemical Pharmaceutics
