摘要
血吸虫疫苗的研究已经纳入了WHO和我国主要疾病防治规划，并且取得了很大的进展。血吸虫疫苗的研究历史经历了从死疫苗、致弱活疫苗、亚单位疫苗、基因工程疫苗、核酸疫苗到多价联合疫苗等的探索过程。近年来开展的血吸虫免疫机制和血吸虫基因组的研究对血吸虫疫苗的研制起到了积极的推动作用。该文主要对日本血吸虫疫苗近十年的研究进展作一综述。
The study on vaccine against Schistosoma has been included into the program of the treat- ment and prevention on the major diseases of WHO and our country with a great progress. The history of the study on vaccines against Schistosoma has passed from dead vaccine, attenuated vaccine, sub-unit vaccine, gene engineered vaccine, nucleic acid vaccine to multivalent affiliate vaccine. Recently, the research progress on immunologic mechanism of Schistosoma and the genome of Schistosoma has played a very important role in the research and development of vaccine against Schistosoma. This article reviewed the development of vaccine against Schistosoma japonicum in recent 10 years.
出处
《国际医学寄生虫病杂志》
CAS
2010年第2期87-93,共7页
International JOurnal of Medical Parasitic Diseases
关键词
日本血吸虫
疫苗
基因组
Schistosoma japonicum
Vaccine
Genome
