摘要
给低碘Wistar大鼠皮肤涂抹含碘制剂4个月后处死，测甲状腺含碘量，血清T4、FT4，并进行体视学观察结果发现；涂含碘制剂组（EI）甲状腺重量减少、甲状腺含碘量、血清T4、FT4较低碘对照组（EIF、C）均明显升高，并接近正常对照组（N）；甲状腺体视学参数显示低碘导致的甲状腺滤泡上皮增生、滤泡腔变小、胶质减少，滤泡边缘不规则等改变，经补碘4个月后发生逆转，体视学参数均趋于正常。可见通过皮肤渗透作用仍可达到补碘的效果；图象分析技术的应用对甲状腺形态变化进行量化，为深入研究甲状腺疾病提供了科学的依据。
Daubing up iodic agent on local skin is a new method for supplementingiodine. Wistar rats fed on low iodine diet for 3 months in order to reproduce animal model ofgoiter. After 4 months to replenish iodine, low iodine rats were executed for further thyroidanalysis and serum iodine content, serum T4, FT4, and observing morphological change by using routine histological method and MIAS-300 image analysis system. The results showedthat daubing up iodic agent group (EI) serum I, T4, FT4, content I of thyroid rose obviouslycompared with low iodine control (EIF, C) and approached the normal (N) level. The dataof stereological analysis showed that the changes of epithelial hyperplasia in thyroid follicle,reducing follicular cavity, colloid lacked, irregular edge of follicular accursed reversion after4 months for supplementing iodine. The data of stereological analysis in rats of EI group tended to be normal (control group). So replanishing iodine through the skin permeated waseffect. Application of image analysis technique supplied scientific evidence for studing thyroid disease further.
出处
《地方病通报》
1998年第4期7-9,共3页
Endemic Diseases Bulletin
基金
天津市自然科学基金!973608011
关键词
碘缺乏病
含碘制剂
甲状腺
体视觉
图象分析
Iodine deficiency
Iodic agent
Thyroid stereology
Image analysis
