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白介素-32及其与炎症性疾病的关系研究进展 被引量：5

Advance in the research of relationship between IL-32 and inflammatory diseases
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摘要 白介素-32是新近发现的一种前炎症反应细胞因子,有6种剪接变异体形式,主要作用是诱导TNFα、IL-1β、IL-6和趋化因子的产生,参与了固有性和适应性免疫应答。研究发现IL-32及其受体与多种自身免疫性炎症性疾病的发生、发展有密切联系,本文就此方面做了总结。 Interleukin-32 is a recently discovered proinflammatory eytokine that induces TNFα,IL-1β,IL-6 and chemokines. It has six isoforms and plays a role in innate/adaptive immunity. IL-32 and IL-32 receptor exhibit many associations with autoimmune inflammatory deseases. This review has summarized the relationships between IL-32/IL-32R and some autoimmune inflammatory deseases.
作者 李莉 宝福凯
机构地区 昆明医学院
出处 《中国热带医学》 CAS 2010年第6期761-762,770,共3页 China Tropical Medicine
关键词 白介素-32 TOLL样受体 Γ干扰素 细胞因子 IL-32 TLRs IFNγ Cytokine
分类号 R392.11 [医药卫生—免疫学]
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参考文献27

  • 1Kim SH,Han SY,Azam T,et al . Interleukin-32: A Cytokine and inducer of TNFa[ J ] . Iwanunity 2005,22:131-142.
  • 2Dahl CA,Schall RP,He HL,et al . Identification of a novel gene expressed in activated natural killer eells and T cells [J] . J.Immunol 1992,148 : 597.
  • 3Carter KL, Cahir-McFarland E, Kieff E . Epstein-Barr virus-induced changes in B-lymphocyte gene expression [J] . J Virol 2002,76: 10427-10436.
  • 4Park GH, Choe J,Choo HJ,et al. Genome-wide expression profiling of 8-chloroadenosine-and-cAMP-treated human neuroblastoma cells using radioactive human cDNA microarray [J] . Exp Mol Med 2002,34:184-193.
  • 5Brown J,Matutes E,Singleton A,et al . Lymphopain,a cytotoxic T and natural killer cell-associated cysteine ptoteinase [J] . Leukemia 1998,12:1771-1781.
  • 6Coda C,Kanaji T,Kanaji S,et al . Involvement of IL-32 in activation-induced cell death in T cells [J] . International Immunology 2006,18: 233-240.
  • 7Shoda H,Fujio K,Yamaguchi Y,et al . Interactions between IL-32 and tumor necrosis factor alpha contribute to the exacerbation of immune-inflammatory diseases [J] . Arthritis Research & Theraphy 2006,8:R166.
  • 8Beutler B,Jiang Z,Georgel G,et al. Genetic analysis of host resistance: Toll-like receptor signalling and immunity at large [J] . Annu Rev Immunol 2006,24 : 353-389.
  • 9Inohara C,McDonald C, Nunez C . NOD-LRR proteins:Role in hostmicrobial interactions and inflammatory diseases [J] . Annu Rev Bioehem 2005, 74:355-383.
  • 10Netea MG,Azam T,Fetwerda G,et al . IL-32 synergizes with nueleotide oligomerization domain (NOD) 1 and NOD2 ligands for IL-1β and IL-6 production through a caspase 1-dependent mechanism[J] . Proe Nad Acad Sci,2005,32:16309-.-6314.

同被引文献67

  • 1吕传真,李振新,张华,戚晓昆,臧敬五.中国多发性硬化及相关中枢神经系统脱髓鞘疾病的诊断和治疗专家共识(草案)[J].中华神经科杂志,2006,39(12):862-864. 被引量：57
  • 2Clerici M. Beyond IL-17 : new cytokines in the pathogenesis of HIV infection. Curr Opin HIV AIDS,2010,5 (2) : 184-188.
  • 3Ramirez P, Ferret M, Gimeno R, et al. Systemic inflammatory response and increased risk for ventilator-associated pneumonia : a preliminary study. Crit Care Med, 2009,37 (5) : 1691-1695.
  • 4Noviek D, Rubinstein M, Azam T, et al. Proteinase 3 is an IL-32 binding protein. Proc Natl Aead Sci USA,2006,103 (9):3316- 3321.
  • 5Kim SH, Han SY, Azam T, et al. Interleukin-32 : a cytokine and inducer of TNF a. Immunity, 2005,22 ( 1 ) : 131-142.
  • 6Lee S, Kim JH, Kim H, et al. Activation of the interleukin-32 pro-inflammatory pathway in response to human papillomavirus infection and over-expression of interleukin-32 controls the expression of the human papiUomavirus oneogene. Immunology, 2011,132 (3) : 410-420.
  • 7. Felaco P, Castellani ML, De Lutiis MA, et al. IL-32 : a newly- discovered proinflammatory cytokine. J Biol Regul Homeost Agents,2009,23 (3) : 141-147.
  • 8Plantinga TS, Costantini I, Heinhuis B, et al. A promoter polymorphism in human interleukin-32 modulates its expressionand influences the risk and the outcome of epithelial cell-derived thyroid carcinoma. Carcinogenesis,2013,34 (7) : 1529-1535.
  • 9Conti P, Youinou P, Theoharides TC. Modulation of autoimmunity by the latest interleukins (with special emphasis on IL-32). Autoimmun Rev,2007,6 (3) : 131-137.
  • 10Bai X, Ovrutsky AR, Kartalija M, et al. IL-32 expression in the airway epithelial cells of patients with Myeobacterium avium complex lung disease. Int Immunol, 2011,23 ( 11 ) : 679-691.

引证文献5

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中国热带医学
2010年 第6期

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