期刊文献+

六味地黄汤加味治疗糖尿病肾病蛋白尿疗效观察 被引量:6

暂未订购
导出
摘要 目的观察六味地黄汤加味治疗糖尿病肾病(DN)蛋白尿的临床疗效。方法将60例DN患者随机分为2组,对照组给予常规治疗,包括糖尿病饮食,低盐、低脂、优质低蛋白饮食,严格控制血压、血糖等。治疗组在常规治疗的基础上加用六味地黄汤内服,4周为1个疗程,2个疗程后观察疗效。结果治疗组总有效率为83%,对照组总有效率53%,2组比较有显著性差异(P<0.01);治疗组治疗后尿蛋白排泄率(UAER)、尿微量白蛋白(ALB)、β2微球蛋白(β2-MG)显著下降,对照组相应指标治疗后变化不明显。结论六味地黄汤能有效降低DN蛋白尿,阻断或延缓DN的进一步发展。
作者 陈塨 李轩
出处 《现代中西医结合杂志》 CAS 2010年第13期1590-1591,共2页 Modern Journal of Integrated Traditional Chinese and Western Medicine
  • 相关文献

参考文献5

二级参考文献16

  • 1Grupp C, Lottermoser J, Cohen DI etal. Transformation of rat inner medullary fibrolastes to myfibrolasts in vitro[ J]. Kidney Int. 1997,52(5) : 1279 - 1290.
  • 2Esteban V, Lorenzo O, Ruperez M, Suzuki Y etal. Angiotensin II, via AT1 and AT2 receptors and NF- kappaB pathway, regulates the inflammatory response in unilateral ureteral obstruction [J].J Am Soc Nephrol. 2004,15(6):1514 -1529.
  • 3Goumenos DS, Brown CB,shortland J, etal. Myofibroblasts, predictors of progression of mesangial IgA nephropathy? Nephrol Dial Transplant, 1994,9(10) : 1418 - 1425.
  • 4Badid C, Desmouliere A, Babici D etal. Interstitial expression of alpha -SMA: an early marker of chronic renal allograft dysfunction [ J ]. Nephrol Dial Transplant, 2002,17 ( 11 ) : 1993 - 1998.
  • 5Pedagogos E, Hewitson T, Fraser I etal. Myofibroblasts and arteriolar sclerosis in human diabetic nephropathy [ J ], Am J Kidney Dis, 1997,29(6) :912 -918.
  • 6Essawy M, Soylemezoglu O, Muchaneta - Kubara EC etal Myofibroblasts and the progression of diabetic nephropathy[ J ]. Nephrol Dial Transplant, 1997,12( 1 ) :43 -50.
  • 7Alpers CE, Hudkins KL, Floege J, etal. Localization of SPARC in developing, mature, and chronically injured human allograft kidneys[ J ]. Kidney Int, 2002, 62 (6) :2073 - 2086.
  • 8Benson SC, Pershadsingh HA, Ho CI etal. Identification of telmisartan as a unique angiotensin II receptor antagonist with selective PPARgamma - modulating activity[ J]. Hypertension, 2004 ,43 (5) :993 - 1002.
  • 9Kuang PP, Berk JL, Rishikof DC etal. NF - kappaB induced by IL- 1 beta inhibits elastin transcription and myofibroblast phenotype[J]. Am J Physiol Cell Physiol,2002,283 (1) :58 -65.
  • 10Piva R, Belardo G, Santoro MG. NF - kappaB : a stress - regulated switch for cell survival[ J]. Antioxid Redox Signal, 2006,8 (3 -4) :478 -486.

共引文献1465

同被引文献111

引证文献6

二级引证文献33

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部