摘要
目的:通过应用Lewis肺癌移植性肿瘤小鼠模型,观察桑黄云芝胶囊的抑瘤及抗转移作用。方法:C57 BL/6小鼠右腋皮下接种Lewis肺癌瘤株,连续ig给药21 d后,处死动物,摘取瘤体称重,并计算肿瘤生长抑制率。剥离鼠肺,用Bouin氏液固定,解剖镜下计数肺部正反面及肺叶间的转移瘤集落数。结果:桑黄云芝胶囊高、中、低3个剂量对Lewis肺癌荷瘤小鼠肿瘤的生长均有明显的抑制作用(与模型组比较,P<0.05),抑瘤率分别为21.2%,21.0%,24.6%。桑黄云芝胶囊高剂量组Lewis肺癌荷瘤小鼠肺转移集落明显少于模型组(P<0.05)。结论:桑黄云芝胶囊对Lewis肺癌荷瘤小鼠肿瘤生长具有明显抑制作用,并可抑制Lewis肺癌荷瘤小鼠的肺转移,以高剂量最为明显。
Objective：To observe the role of Phellinus Linteus and Coriolus Versicolor Capsules（PLCVC） on anti-tumor and anti-metastasis in Lewis lung cancer tumor mice model.Methods： Lewis lung cancer cells were inoculated subcutaneously into right axillary of C57BL /6 mice,after continuous treatment of 21 d,we sacrificed the mice,removed tumor and weighed,and calculated the rate of tumor growth inhibition.We stripped lungs,fixed by Bouin＇s solution,and counted colony number of metastases on the surface of the lungs and between the lobe under anatomical microscope.Results： High,medium and low doses of PLCVC inhibited significantly Lewis lung cancer tumor growth in the tumor-bearing mice（compared with the model group,P 0.05）,inhibitory rates were respectively 21.2%,21.0% and 24.6%.The colony number of metastases of high dose of PLCVC was less than the model group（P 0.05）.Conclusion： PLCVC can inhibit significantly Lewis lung cancer tumor growth of the tumor-bearing mice,and inhibit lung metastases of Lewis lung tumor-bearing mice,and the effect of high dose is the most obvious.
出处
《中国实验方剂学杂志》
CAS
北大核心
2010年第4期128-130,共3页
Chinese Journal of Experimental Traditional Medical Formulae
关键词
桑黄云芝胶囊
LEWIS肺癌
抑瘤率
Phellinus Linteus and Coriolus Versicolor Capsules
Lewis lung cancer
inhibitory rate of tumor
