摘要
目的对比甲泼尼龙琥珀酸钠和氢化可的松琥珀酸钠在中重度毛细支气管炎中的治疗价值。方法选择符合条件的毛细支气管炎患儿134例,随机分组比较了70例甲泼尼龙琥珀酸钠1mg.kg-1.d-1,分2次静脉注射(A组)和64例氢化可的松琥珀酸钠5mg.kg-1.d-1,分2次静脉注射(B组)治疗,观察呼吸频率、肺部哮鸣音、三凹征等病情变化情况以及住院时间。结果甲泼尼龙琥珀酸钠组患儿喘息、肺部体征好转情况明显优于氢化可的松琥珀酸钠组,而总住院时间2组差异无统计学意义。结论甲泼尼龙琥珀酸钠对于毛细支气管炎症状缓解作用强于氢化可的松琥珀酸钠。
Objective To elucidate the difference between methylprednisolone and hydrocortisone in the treatment of moderate and severe bronchiolitis. Methods This was a randomized, controlled clinical trial in 134 hospitalized children （1 month to 2-year-old） with moderate and severe bronchiolitis. All the children were randomly divided into A and 13 groups. The children in A group were treated with methylprednisolone（1 mg·kg^-1·d^-1 , iv,Bid）, those in B group were treated with hydrocortisone （ 5mg·kg^-1·d^-1, iv ,Bid） , other traditional methods were used as well . We measured the breathing rate, wheezing sound and three concave sign, as well as length of stay. Results The patients in the A group were more improved than those of 13 group （P〈0.05）. But there is no significant difference in the length of stay （P〉0.05）. Conclusion Methylprednisolone was better for the relief of symptoms of bronchiolitis than hydrocortisone sodium succinate.
