摘要
合成具有高效抗病毒，抗癌，抗－ＨＩＶ活性的拟核苷类药物和探索这类化合物的化学结构与生物活性作用的关系已成为有机合成的一个很热门研究课题。在化学合成方面主要着重于核糖结构或碱基结构的优化处理以便提高这类物质的生物活性。概述了目前该领域从天然核苷的结构优化到人工合成拟核苷类药物研究过程的一系列新进展。针对以异恶唑烷（恶唑啉）杂环取代核苷中的核糖结构为代表的拟核苷类化合物的最新研究思路及合成方法作了详细归纳。并简单介绍该领域内较适用的符号表示系统的应用。
It has become a more interesting organic synthesis project to attempt the preparation of novel nucleoside analog agents with remarkable antiviral antitumor anti-HIV activities and to study the chemical-activity relationships. To improve the bioactivity of nucleoside analogs,almost all the chemical synthesis works mainly focus on the structure modification of the sugar moiety or the base moiety.The recent developments of research on the modification of natural nucleosides and the production of nonnuceosides as potent active agents were introduced in this paper.And a series of latest designed synthesis methods of novel nucleoside analogs in which the sugar moiety was replaced by isoxazolidinyl(isoxazolinyl) heterocycles were well detailed. The use of notation system in this area was also introduced.
出处
《江苏石油化工学院学报》
1998年第4期61-64,共4页
Journal of Jiangsu Institute of Petrochemical Technology
