摘要
目的观察长期吸烟对血管内皮功能的影响。方法采用超声肱动脉内径测量法，观察了30例长期吸烟者左上肢肱动脉内径对反应性充血和含服消心痛的反应性变化，以另外30例非吸烟正常人作为对照组。结果在基础状态下，吸烟组和非吸烟组肱动脉内径基本相同（P＞0.05；反应性充血后，吸烟组肱动脉内径变化明显小于对照组（114±1.7）%比（19.1±1.6）％，P＜0．05，含服消心痛后两组肱动脉内径变化基本相同（19．4±1.8）％比（21．6±2．1）％，P＞0.05。结论长期吸烟对人体血管内皮依赖性舒张功能具有明显损害，而对非内皮依赖性舒张功能影响不大，这种血管内皮损伤变化在心血管病的发病中的作用尚待进一步研究。
Objective: To observe the influence of long history of smeking on the blood endothelium function. Methods: The reactive changes of the dianmeters of right bracial artery in 30 cases with a long history of smokingto the reactive hyperimia and sucking isosorbide dinitrate were observed. And 30 normal people without smoking history were a control group. Results: Under hasal condition, the diameters in smokers and those in non-smoders were al most the same (P>0.05 ); after the reactive hyperemia, the diameters in smokers changed much less than those innon-smokers (11 .4± 1 .7) %: (19. 1± 1 .6) % (P < 0.05 ). Aner sucking i^rbide dritl'ate, the changes of diameters in the two groups were almost the same (19.4± 1 .8) %: (21 .6±2. 1 ) % (P > 0.05). Conclusion: It is suggested that long history of smoking is remarkably harmful to the dependence diastolic function Of blood endotheliumwhile it is less harmful to the independence diastolic function of blabs endothelium. The effect of changes of immuredblood endothelium on the ocurence of angiocardiopathy still needs futher study.
出处
《泰山医学院学报》
CAS
1998年第4期295-297,共3页
Journal of Taishan Medical College
