摘要
以乙醇胺为原料用液相法经成盐酸盐化及氯化两步反应合成２氯乙胺盐酸盐，研究了反应的主要影响因素。成盐反应在室温下，乙醇胺与浓盐酸１∶１条件下中和反应。氯化反应以甲苯为溶剂，乙醇胺盐酸盐与二氯亚砜的摩尔比为１∶１０４，反应温度６６℃，反应时间２５ｈ，获得了最佳反应结果，产品总收率９５８％，纯度９９１％。
2-Chloro-ethylamine hydrochloride was synthesized from ethanolamine by hydrochlorination followed by reaction with thionyl chloride.A study of the effects on the synthesis was done,which gave the optimum conditions that hydrochlorination was run at room temperature with 1∶1 molar ratio of ethanolamine to hydrochloride followed by reaction with thionyl chloride at 66℃ for 2.5h with 1∶1.04 molar ratio of ethanolamine hydrochloride to thionyl chloride and with methylbenzene used as solvent.The total yield is 95.8% in 99.1% purity.
出处
《精细化工》
EI
CAS
CSCD
北大核心
1998年第2期48-50,共3页
Fine Chemicals
关键词
氯乙胺盐酸盐
乙醇胺
合成
工艺
2-chloro-ethylamine hydrochloride,ethanolamine,synthesis
