期刊文献+

甲基强的松龙治疗小儿哮喘的临床疗效观察 被引量:2

Clinical effect of methyprednisolone on children asthma
暂未订购
导出
摘要 目的观察甲基强的松龙治疗小儿支气管哮喘的临床疗效。方法支气管哮喘(包括婴幼儿哮喘,儿童哮喘)患儿100例随机分为两组,治疗组与对照组各50例,治疗组在常规治疗的基础上加用甲基强的松龙1-2mg/kg·d,对照组在常规治疗的基础上加用氢化可的松5-10mg/Kg·d,两组均连用5天,治疗结束后比较两组的治疗效果。结果治疗组在喘息与哆音消失以及住院时间均较对照组明显缩短,其结果差异具有统计学意义(P〈0.05)。结论甲基强的松龙对于治疗小儿支气管哮喘具有明显疗效,且安全,副作用小,具有临床推广意义。 Objective To investigate the therapeutic effect of methyprednisolone on acute episode of children asthma. Method 100 patients with acute episode of children asthma was randomly divided into two groups. 50 cases were treated with methyprednisolone under normal treatment (treatment group). Another 50 cases were treated with hydrocortisone under normal treatment (control group), Result The elimination time of gasping, rale and length of day in the treatment group was significantly lower than that in the control group(P〈0.05). Conclusion Methyprednisolone is useful and safe in treatment of acute episode of children asthma.
出处 《西部医学》 2010年第4期658-659,共2页 Medical Journal of West China
关键词 甲基强的松龙 儿童 哮喘 Methyprednisolone Child Asthma
  • 相关文献

参考文献7

二级参考文献32

  • 1陈新谦 金有豫.新编药物学,第14版[M].人民卫生出版社,1998.532.
  • 2贾博琦 鲁玉兰.现代临床药物手册,第11版[M].北京:北京医科大学中国协和医科大学联合出版社,1996.501.
  • 3全国儿科哮喘防治协作组,中华儿科杂志,1998年,36卷,12期,747页
  • 4陈新谦,新编药物学(第14版),1998年,421页
  • 5贾博琦,现代临床药物手册(第11版),1996年,501页
  • 6Rohatagi S,Hochhaus G,Mollmann H,et al.Pharmacokinetics interaction between endogenous cortisol and exogenous corticosteroids[J].Pharmazie 1995,50(9):610-613.
  • 7Boudinot FD,Jusko WJ.Plasma protein binding interaction of prednisone and prednisolone[J].J Steroid Biochem 1984,21 (3):337-339.
  • 8Lewis GP,Jusko WJ,Graves L,et al.Prednisone side-effects and serum-protein levels:a collaborative study[J].Lancet 1971,Ⅱ (7728):778-780.
  • 9Diederich S,Eigendorff E,Burkhardt P,et al.11 β-hydroxysteroid dehydrogenase types 1 and 2:an important pharmacokinetic determinant for the activity of synthetic mineralo-and glucocorticoids[J].J Clin Endocrinol Metab 2002,87 (12):5695-701.
  • 10Ebling WF,Milsap RL,Szefler SJ,et al.6αmethylprednisolone and 6αmethylprednisolone plasma protein binding in humans and rabbits[J].J Pharm Sci 1986,75(8):760-763.

共引文献219

同被引文献15

引证文献2

二级引证文献1

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部