摘要
ＭＡＰＫ级联途径在真核生物细胞的信号传递过程中起着重要的作用．ＭＡＰＫ级联途径由ＭＡＰＫ、ＭＡＰＫＫ和ＭＡＰＫＫＫ三类酶蛋白组成．这三类蛋白质的结构非常保守，通过磷酸化作用传递各种信号．在酵母和动、植物细胞中已经发现了一系列的ＭＡＰＫ级联途径成员，使真核生物的信号传递途径逐渐得到阐明．
Mitogen activated protein kinase (MAPK) cascades play essential roles in the signal transductions in eukaryotie. The MAPK cascades are composed of MAPK (mitogen activated protein kinase), MAPKK (mitogen activated protein kinase kinase) and MAPKKK (mitogen activated protein kinase kinase kinase). These kinases are structurally conserved, and transduct signals via protein phosphorylation. Many kinases and genes of yeasts, animals and plants which are involved in the MAPK cascades have been isolated and characterized. From these investigations , the signal trasduction pathways of eukaryotic cells gradually become clear.
出处
《生物化学与生物物理进展》
SCIE
CAS
CSCD
北大核心
1998年第6期496-503,共8页
Progress In Biochemistry and Biophysics
基金
国家自然科学基金
