摘要
目的探讨新生儿先天性巨细胞病毒(CMV)感染患儿血清β2微球蛋白(β2-MG)检测的意义。方法采用微粒子免疫定量分析法对确诊的新生儿先天性CMV感染患儿(观察组)及同期住院的其他新生儿(对照组)测定血清β2-MG,并进行比较,观察组与对照组病例数比例为1∶2;建立血清β2-MG诊断CMV感染的工作曲线,确定ROC曲线下的面积,同时分析不同截断值的敏感度和特异度。结果观察组共21例,血清β2-MG值为(3112±910)μg/L,对照组共42例,为(2470±624)μg/L,差异有统计学意义(P<0.01);取观察组血清β2-MG3000μg/L为截断值,其敏感度为52.38%,特异度为82.71%。结论血清β2-MG可作为先天性CMV感染诊断的辅助指标,便捷实用,适于基层医院临床开展。
Objective To evaluate the role of serum β2-microglobulin （β2-MG） in neonatal congenital cytomegalovirus （CMV） infection. Methods β2-MG was tested in 21 neonates confirmed congenital CMV infection （observaiton group） and 42 neonates without CMV infection （control group） using microparticle enzyme immunoassay. β2-MG levels were compared between the two groups to assess the effect of different cut-off levels on specificity and sensitivity in the diagnosis of neonatal congenital CMV infection. Results Mean （±SD）β2-MG level were significantly higher in the observation group （3112±910 μg/L） than in the control group （2470±624 μg/L） （P〈0.01）. There was a sensitivity of 52.38% and specificity of 82.71% with the cut-off value of β2-MG 3000 μg/L in the observation group. Conclusion The measurement of serum β2-MG is one of an useful adjuvant marker in diagnosing neonatal congenital CMV infection,particularly in hospitals under level Ⅲ.
出处
《中国新生儿科杂志》
CAS
2010年第2期86-88,共3页
Chinese Journal of Neonatology
关键词
巨细胞病毒感染
Β2微球蛋白
婴儿
新生
Cytomegalovirus infections
Beta2-microglobulin
Infant, newborn
