摘要
目的探讨细胞学联合癌胚抗原(CEA)、肿瘤抗原19-9(CA19-9)和细胞角蛋白片段(CY-FRA21-1)检测,在鉴别非典型良恶性胸腔积液中的参考价值。方法对200例细胞学发现非典型细胞的胸水用电化学发光法测定其上述3种肿瘤标志物的含量,用t检验对两样本均数进行比较并根据公式计算出3种肿瘤标志物对良恶性胸水诊断的敏感性、特异性和准确性。结果经证实为恶性胸水组的3种肿瘤标志物水平显著高于良性组(P<0.05),CEA的准确性最高;CA19-9的特异性最好,但敏感度低;CY-FRA21-1的准确性与CA19-9相近。结论CEA、CA19-9和CYFRA21-1联合检测,对细胞学鉴别胸腔积液中非典型细胞的性质具有一定的参考价值,对于可疑病例需多次送检,尽可能找到典型的恶性肿瘤细胞,为临床提供准确、及时、可靠的依据。
Objective To study the value of cytological examination combining the level of carcino-embryonic antigen （CEA）,carbohydrate antigen 19-9 （CA19-9） and cytokeratin fragment antiogen 21-1 （CYFRA21-1） in diagnosing atypia benign pleural Fluids or malignant ones. Methods Test the level of the three tumor markers above by electrochemical luminescent technique among the 200 pleural fluids where atypical cells were found by cytological examination,t-analysis was undertook to compare the mean of the two groups,calculate the sensitivity,specificity and correctness of the three tumor markers in diagnosing the benign pleural fluids or malignant ones. Results The level of the three tumor markers in the malignant pleural Fluid group was obviously higher than that in the benign one（P0.05）,the diagnostic correctness of CEA was topmost,the diagnostic specificity of CA19-9 is first-rate but sensitivity was low,the diagnostic correctness of CYFRA21-1 was similar to that of CA19-9.Conclusion It mihgt be helpful to test the level of CEA,CA19-9 and CYFRA21-1 when atypical cells are found in the pleural fluids by cytological examination ,to those doubtful case ,more number of times specimen are needed to find out the typical malignant tumor cells so as to provid an accurate and reliable report for the clinic in time.
出处
《黑龙江医学》
2010年第3期180-182,共3页
Heilongjiang Medical Journal
关键词
胸腔积液
非典型细胞
癌胚抗原
肿瘤抗原19-9
角蛋白片段
Pleural effussion
Atypical cells
Carcino-embryonic antigen
Carbohydrate antigen 19-9
Cytokeratin fragment antiogen 21-1
