期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

类风湿关节炎患者转运蛋白基因多态性与甲氨蝶呤疗效及安全性的相关性研究进展 被引量：3

Research progress of relationship between the single nucleotide polymorphisms of transporters genes and the efficacy and safety of methotrexate in rheumatoid arthritis patients
暂未订购
导出
摘要 甲氨蝶呤是治疗类风湿关节炎应用最广泛的药物之一,其疗效及不良反应个体差异很大。本文介绍了人体甲氨蝶呤转运蛋白的结构和功能,并阐明其基因单核苷酸多态性可能对药物反应的个体差异。 Methotrexate modifying antirheumatic efficacy and toxicity has （MTX） is one of the most widely used disease - drug for the treatment of rheumatoid arthritis. Its significant differences among patients. This article introduces structures and functions of human MTX transporters, and clarifies their single - nucleotide polymorphisms in genes coding for trans- porters are probably related with differences of drug reactions among patients.
作者 蔡静 徐建华
机构地区 安徽医科大学附属医院风湿科
出处 《中国临床药理学杂志》 CAS CSCD 北大核心 2010年第3期231-235,共5页 The Chinese Journal of Clinical Pharmacology
关键词 甲氨蝶呤 类风湿关节炎 转运蛋白 单核苷酸多态性 methotrexate rheumatoid arthritis transporters single - nucleotide polymorphisms
分类号 R593.21 [医药卫生—内科学] R971.1 [医药卫生—药品]
  • 相关文献

参考文献37

  • 1Urano W,Taniguchi A,Yamanaka H,et al.Polymorphisms in the methylenetetrahydrofolate reductase gent were associated with both the efficacy and the toxicity of methotrexate used for the treatment of rheumatoid arthritis,as evidenced by single locus and haplotype analyses[J].Pharmacogenetics,2002 ; 12:183-190.
  • 2Wessels JA,deVries-Bouwstra JK,Heijmans BT,et al.Efficacy and toxicity of methotrexate in early rheumatoid arthritis are associated with single-nucleotide polymorphisms in genes coding for folate pathway enzymes[J].Arthritis Rheum,2006 ;54:1087-1095.
  • 3Wada M.Single nucleotide polymorphisma in ABCC2 and ABCB1 genes and their clinical impact in physiology and drug response[J].Cancer Lett,2006 ;234:40-50.
  • 4Hediger MA,Romero MF,Peng JB,et al.The ABCs of solute carriers:physiological,pathological and therapeutic implications of human membrane transport proteins Introduction[J].Pfluegers Arch,2004 ;447:465-468.
  • 5Hooijberg JH,Broxterman HJ,Kool M,et al.Antifolate resistance mediated by the multidrug resistance proteins MRP1 and MRP2[J].Cancer Res,1999 ;59:2532-2535.
  • 6Ken-ichi H,Keiko F,Masanori T,et al.Involvement of reduced folate carrier 1 in the inner blood-retinal barrier transport of methyltetrahydrofolate[J].Drug Metab Pharmacokinet,2008;23:285-292.
  • 7Brzezinska A,Winska P,Balinska M,et al.Cellular aspects of folate and antffolate membrane transport[J].Acta Biochim Pol,2000; 47:735-749.
  • 8Chango A,Emery-Fillon N,de Courcy GP,et al.A polymorphism (80G-》A) in the reduced folate carrier gene and its associations with folate status and homocysteinemia[J].Mol Genet Metab,2000; 70:310-315.
  • 9Prabha R,Howard L Methotrexate pharmacogenetics:the first step toward individualized therapy in rheumatoid arthritts[J].Arthrit Rheumat,2006 ;54:1366-1377.
  • 10Gerrit J,Joost von der H,Ruud O,et al.Sulfasalzine is a potent inhibitor of the reduced folate carrier.Implications for combination therapies with methotrexate in reumatoid arthritis[J].Arthrit Rheumat,2004;50:2130-2139.

同被引文献36

  • 1高科攀,王峰,蒋新国,陆国椿.大鼠血浆和脑脊液中甲氨蝶呤浓度测定及其应用[J].中国临床药学杂志,2005,14(1):23-26. 被引量：10
  • 2水文波,贺庆,葛志伟,程翼宇.高效液相色谱-质谱联用法研究芍药苷的大鼠小肠吸收[J].中国药学杂志,2007,42(14):1098-1101. 被引量：6
  • 3Varani K, Vincenzi F, Tosi A, et al. Expression and functional role of adenosine receptors in regulating inflammatory responsesin human synoviocytes[J]. Br J Pharmacol, 2010, 160(1): 101- 115.
  • 4Milne GR, Palmer TM. Anti-inflammatory and immunosuppres- sive effects of the A2A adenosine receptor[J]. Sci World J, 2011, 11(1): 320-339.
  • 5Drozdzik M, Rudas T, Pawlik A, et al. Reduced folate carrier-1 80G>A polymorphism affects methotrexate treatment outcome in rheumatoid arthritis[J]. Pharmacogenomics J, 2007, 7(6): 404- 407.
  • 6Samara SA, Irshaid YM, Mustafa KN. Association of MDR1 C3435T and RFC1 G80A polymorphisms with methotrexate toxicity and response in jordanian rheuhaatoid arthritis patients[J]. Int J Clin Pharmacol Ther, 2014, 52(9): 746-755.
  • 7?wierkot J, Slszak R, Karpifiski P, et al. Associations between single-nucleotide polymorphisms of RFC-1, GGH, MTHFR, TYMS and TC Ⅱ and the efficacy and toxicity of methotrexate treatment in patients with rheumatoid arthritis[J]. Pol Arch Med Wewn, 2015, 125(3): 152-161.
  • 8Kato T, Hmuada A, Mori S, et al. Genetic polymorphisms in metabolic and cellular transport pathway of methotrexate impact clinical outcome of methotrexate monotherapy in Japanese pa- tients with rheumatoid arthritis[J]. Drug Metab Pharmacokinet, 2012, 27(2): 192-199.
  • 9Hayashi H, Fujimaki C, Daimon T, et al. Genetic polymor- phisms in folate pathway enzymes as a possible marker for pre- dicting the outcome of methotrexate therapy in Japanese patients with rheumatoid arthritis[J]. J Clin Pharm Ther, 2009, 34(3): 355-361.
  • 10Jekic B, Lukovic L, Bunjevacki V, et al. Association of the TYMS 3G/3G genotype with poor response and GGH 354GG genotype with the bone marrow toxicity of the methotrexate in RA patients[J]. Eur J Clin Pharmacol, 2013, 69(3): 377-383.

引证文献3

二级引证文献8

中国临床药理学杂志
2010年 第3期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部