摘要
目的:探讨射频消融对正常兔肝损伤后,机体在不同时间点肝功能的变化情况。材料和方法:20只健康新西兰白兔,在超声引导下行射频消融术,分别于术前及术后1、3、5、7和14d抽取耳缘静脉血进行肝功能的测定,在动物处死前后分别在超声二维图像和肝标本上测量射频消融毁损区的范围,并对肝标本行病理检查,将肝功测定结果与病理改变综合分析。结果:射频消融后,血清总蛋白、白蛋白在第1天开始下降,第3天降到最低;天冬氨酸转氨酶、丙氨酸转氨酶、碱性磷酸酶第1天开始明显增高,第3天达最高值。碱性磷酸酶在第7天恢复正常,其余指标均在第7天开始恢复,第14天恢复到正常,以上肝功能变化与射频消融毁损区范围有关,且与消融后病理相对应。结论:正常兔肝射频消融后,射频消融毁损区范围越大,肝功能变化越大,且均在14d内自行恢复。
Purpose To investigate the time-serial changes of liver function after radiofrequency ablation （RFA） in normal rabbits. Materials and Methods Ultrasound-guided liver RFA were applied on 20 healthy New Zealand＇s white rabbits. The laboratory tests of liver functions were sampled from rabbit ear vein before and after RFA at 1、3、5、7、14 days. The extent of injury of the liver induced by RFA was assessed by ultrasound and compared with that of postmortem pathology. Results After RFA,total protein and albumin fell down at day 1,reaching nadir at day 3. ALT AST AKP rose up obviously at day 1,reaching peak at day 3. AKP returned to normal at day 7,while the other markers started to recover. All the liver function markers returned to normal at day 14. The change of the liver＇s function was correlated to the extent of RFA injury and its pathology. Conclusion The liver function was altered after RFA over 2 weeks and the change was correlated to the extent of injury in normal rabbit.
出处
《中国医学影像学杂志》
CSCD
北大核心
2010年第2期147-149,共3页
Chinese Journal of Medical Imaging
关键词
超声检查
导管消融术
肝功能试验
ultrasonography
catheter ablation
liver function tests
