摘要
目的：探讨与非角化性鼻咽癌（ｎａｓｏｐｈａｒｙｎｇｅａｌｃａｒｃｉｎｏｍａ，ＮＰＣ）转移有关的主要因素。方法：采用逐步回归的方法，对８３例非角化性ＮＰＣ１５项可能与转移有关的因素进行筛选。结果：在不同的Ｆ值水平下筛选出与ＮＰＣ转移发生最相关的因素，它们是癌内血管密度，血管壁上层粘蛋白（ＬＮ）表达异常，癌巢内淋巴细胞（ＬＣ）浸润量，癌细胞间变程度与患者年龄。这５个因素包括在逐步回归方程中（Ｙ＝１．４７６８－０．０９５７Ｘ１＋２．６６５Ｘ３＋０．００３１Ｘ９－０．２９４８Ｘ１３－０．３１０Ｘ１５，ＭＲ＝０．７０７４ｓｘ＝０．６４８９Ｆ＝１５．４２４７Ｐ＜０．０１），进而用方程进行回顾性推断８３例ＮＰＣ转移率为７３．４９％，明显高于临床记录发现的转移率（５９．０４％）。结论：逐步回归方程的建立为临床正确判断ＮＰＣ转移。
Purpose This study was designed to find the main clinico pathological factors which influence non keratinizing nasopharyngeal carcinoma (NPC) metastasis. Methods The influence of 15 clinico pathological factors on NPC metastasis was analyzed by stepwise regression model in 83 cases of NPC. Results The most correlated factors affecting NPC metastasis were screened out under different F levels, they were (1) blood vessel density in tumour stroma ( X 9); (2) laminin abnormally expressed on the vessel wall of tumour tissue ( X 13 ); (3) the amount of lymphocytic (LC) infiltration in carcinom nest ( X 15 ); (4) tumour cells anaplasia ( X 3); (5) the patients age ( X 1). These factors were included in the equations. Y =1 4768-0 0957 X 1+2 665 X 3+0 0031 X 9-0 2948 X 13 -0 310 X 15 (MR=0 7074 s =0 6489 F =15 4247 P <0 01). 73 49% metastatic rate of 83 NPC were detected by stepwise regression equation, which was significantly higher than clinical detected metastatic rate (59 04%). Conclusion The chief factors are suggested to serve as observation indexes of an ordinary pathologic examination in the diagnosis of NPC metastasis, so that an accurate diagnosis can be made with the help of the regression equations and proper therapies on NPC patients can be given to.
出处
《临床与实验病理学杂志》
CAS
CSCD
1998年第6期525-528,共4页
Chinese Journal of Clinical and Experimental Pathology
基金
美国CMB基金
关键词
鼻咽肿瘤
肿瘤转移
逐步回归法
nasopharyngeal neoplasms
neoplasm metastasis
regression analysis
