摘要
目的研究血清 DNA 酶(DNase)浓度异常在系统性红斑狼疮(SLE)发生发展中所起的作用。方法于国内首次用单和酶扩散法检测了63例 SLE 患者结果患者血清中 DNase 浓度明显低于正常人;活动期患者明显低于缓解期患者;SLE 伴肾损害患者低于非肾损害患者。血清 DNase 的浓度下降与 DNA 含量升高呈负相关;与血沉、ANA 呈负相关;与补体 C3、C4呈正相关;与病情活动积分呈负相关结论 SLE 患者由于其 DNase 水增低下,使得血循环中含 DNA 的自身抗原长期滞留,发挥免疫原性,并与抗 DNA 抗体结合形成免疫复合物,造成免疫损伤。患者血清 DNase 水平低下在 SLE 的发病机制中起着一定作用。
Objective To study the role of abmormal comeetration,of DNase in the development,of SLE.Methods The coneentration of DNase was measured by single radial enzynme diffusion method in the sera of 63 SLE patients.Results The coneentration of DNase in the patients was significantly lower tha in healthy indivduals,signifieantly lower patients at active slage than in remission,and Iowest in patients with lupus nephrilis.The deerease of serum DNase was negatively eorlreIated with the increase of serum DNA. The level of DNase was Hegatively correlated with ANA and ESR.positively correlated with C3.C4.and neg- alively correlated with the severitv of the disease Conclusion The above data suggest that the decrease of serum DNase make,the persistence of DNA in the blood eireulation which combines with antiDNA antibody to form immune complex resulting in autoimmune lesions.The deereaset of serum DNase an important role in the pathogenesisSLE.
出处
《中华皮肤科杂志》
CAS
CSCD
北大核心
1998年第6期354-356,共3页
Chinese Journal of Dermatology
