摘要
为探讨体外循环（ＣＰＢ）心脏手术病人降钙素基因相关肽（ＣＧＲＰ）的变化和临床意义，对１５例先天性心脏病和１１例风湿性心脏病（男１９例，女７例；年龄６～５６岁；体重１３～６８ｋｇ）行ＣＰＢ心脏手术的病人，采血用放免法测定ＣＧＲＰ含量。结果麻醉后转流前、阻断主动脉２０、４０分钟、开放主动脉即刻、开放后２０、４０分钟、术后６小时和术后１０天共８个时点ＣＧＲＰ含量分别为２．３９２±１．３７５、７．４８２±６．７９３、４．６６６±２．７１２、６．５４０±４．５００、７．８２６±７．２６９、９．２８９±４．９７６、５．２４２±４．０１４、３．９８３±２．８８７ｐｍｏｌ／Ｌ。与转流前比较，ＣＧＲＰ含量在阻断主动脉至开放主动脉明显升高，开放主动脉４０分钟达高峰（Ｐ＜０．００１），术后６小时稍有回落，但仍高于转流前（Ｐ＜０．００５），术后１０天虽显著回落，但仍显著高于转流前水平（Ｐ＜０．０５）。
Aim:The purpose of current study was to evaluate the changes of calcitonin gene related peptide(CGRP) and their clinical significance on patients undergoing open heart surgery under cardiopulmonary bypass(CPB).Clinical material and method:The content of CGRP was studied in 26 patients(15 with congenital heart disease and 11 with rheumatic valve disease)using radioimmunoassay method.There were 19 males and 7 females with a mean age of 23.4±18.25 years(range,6 to 56 years).Blood samples were taken at eight different time intervals.Result:The content of CGRP was increased significantly during CPB when compared to its basic level before CPB(P<0.001).The content of CGRP reached its highest level at 40 minute after releasing aortic cross clamping.On 10 postoperative day the CGRP decreased significantly but is was still higher than basic level.Cononclusion:The elevation of CGRP may play an important role in myocardial protection during CPB.
出处
《中华胸心血管外科杂志》
CSCD
北大核心
1998年第6期345-347,共3页
Chinese Journal of Thoracic and Cardiovascular Surgery
关键词
体外循环
心脏外科手术
CGRP
Cardioplumonary bypass Calcitonin gene related peptide
