摘要
目的研究臭氧水对感染性创面的抗炎与修复作用的效果。方法将50只vista大鼠随机分成5组,洗必泰治疗组、低、中、高浓度臭氧水治疗组、对照组(不做特殊处理)各10只。首先在大鼠背部造成实验性感染性伤口,感染成功后48h进行治疗,每天1次,9d为1疗程。在治疗前、治疗后3、6、9d后分别对感染伤口的变化进行观察,抽取鼠尾静脉血检查白细胞计数,切取皮肤、肌肉组织标本进行光镜病理分析。结果与结论综合各项指标,各臭氧水治疗组的效果明显优于对照组以及洗必泰治疗组,其中10mg/L与20mg/L浓度组的优于5mg/L组,前两者治疗效果相当。
Objective To study the effect of ozone water in promoting the healing of infected wounds. Methods Fifty Wistar rats were randomly divided into 5 groups, namely chlorhexidine treatment group, 5, 10, and 20 mg/L ozone water treatment groups, and the control group without any treatment. Infected wounds were induced on the back of the rats, and at 48 h of infection, chlorhexidine or ozone water was applied once daily for 9 days. Before and at days 3, 6, and 9 of the treatment, the wound changes were observed. The WBC in the tail venous blood was detected and the incised skin and muscular tissues were pathologically examined. Results and conclusion Ozone water showed better effects in promoting the healing of the infected wound, especially at higher doses of 10 and 20 mg/L.
出处
《南方医科大学学报》
CAS
CSCD
北大核心
2010年第3期515-518,共4页
Journal of Southern Medical University
基金
广东省自然科学基金(8151051501000079)
关键词
臭氧水
感染性创面
抗炎修复
wound infection
ozone water
inflammation
repair
