摘要
宫颈癌在世界范围内发病率位居女性恶性肿瘤的第2位。高危型人乳头瘤病毒生殖道持续感染被认为是引起宫颈癌前病变——宫颈上皮内瘤变及宫颈癌的主要病因。宫颈癌存在着一个较长的、可逆转的癌前病变期,故对宫颈癌的筛查及对宫颈上皮内瘤变的治疗处理一直受到关注。该文就人乳头瘤病毒导致宫颈癌的机制及其检测的临床应用等研究进行综述。
Cervical cancer remains the second most common malignancy in women worldwide. The persistant infection of highrisk genotypes of human papilloma virus(HRHPV) in the genital tract is thought the main cause of precancerous lesion—cervical intraepithelial neoplasia(CIN) and cervical cancer. Cervical cancer has a long reversible precancerous stage, so the screening of cervical cancer and treatment of CIN have attracted more attention for a long time. This article reviewed the major mechanisms that HPV causes cervical cancer and clinical application of detection of HPV DNA in cervical secretions.
出处
《中国妇幼健康研究》
2010年第2期253-255,共3页
Chinese Journal of Woman and Child Health Research
基金
【基金项目]石河子大学医学院第一附属医院院级科研资助项目(YL2008-Y002)
关键词
人乳头瘤病毒
宫颈癌
宫颈上皮内瘤变
第2代杂交捕获试验
human papillomavirus (HPV)
cervical cancer
cervical intraepithelial neoplasia (CIN)
hybrid capture 2 (HC2)