摘要
本文合成19个新的N-(2,2,5,5-四甲基-3-吡咯啉-1-氧自由基)-N-(酰胺基)脲化合物.研究了此类化合物的ESR,MS及IR波谱性质.初步观察了此类化台物对白血病L7712癌细胞以及腹水型肝癌细胞的抑制作用.发现有的化合物抑制效果显著.
By the addition of l-oxyl-2, 2, 5, 5-tetramethyl-pyrroline-3-isocyanate ( I ), synthesized by seven steps,to substituted hydrazides with biological activity, nineteen N-carbamoyl-N'-( 1-oxyl-2,2,5,5-tetramethyl-pyrrolin-3-yl) urea compounds were synthesized, The characteristics of electron spin resonance spectra, infrared spectra and mass spectra of some typical compounds of ( Ⅲ ) were discussed. The preliminary experiment showed that compounds ( Ⅲ ) possess a inhibiting activity on L7712-leukemia cell and ascitic hepatoma. Especially, the activity of ( Ⅲ )e, as well as of ( Ⅲ )g are more striking.
出处
《高等学校化学学报》
SCIE
EI
CAS
CSCD
北大核心
1989年第12期1202-1207,共6页
Chemical Journal of Chinese Universities
关键词
吡咯啉
氮氧自由基
异氰酸酯
药物
Pyrroline nitroxyi radical, Isocyanate, Anticancer activity
