摘要
目的探讨深静脉血栓(DVT)与叶酸、维生素B12(VB12)、超重/肥胖等营养因素及吸烟、饮酒等高危行为因素的相关性。方法采用病例对照研究的方法,以确诊为DVT的患者及同期门诊体检的健康对照各50例为研究对象,进行流行病学资料调查和膳食调查,同时测定血中叶酸、VB12含量,分析DVT与膳食叶酸、VB12摄入、血中叶酸、VB12水平以及体质量指数(BMI)、吸烟、饮酒等因素的关系。结果在调整其他因素的多元分析中,血叶酸水平偏低(P=0.003 2,OR=0.149)、日常膳食叶酸摄入不足(P=0.003 5,OR=0.210)、超重/肥胖(P=0.035 4,OR=2.632)等因素入选,使DVT危险性增加。结论血中低叶酸水平、膳食叶酸摄入不足、超重/肥胖等因素均使DVT发生的危险性升高。
Objective To investigate the correlation of folic acid, vitamin B12 with smoking, drinking and deep venous thrombosis （DVT）. Methods By using case-control study design, 50 DVT patients were included in this study as patient group and 50 healthy subjects as control group. Epidemiological and diet survey were made. Radio-immunoassay was used to measure serum folic acid and vitamin B12. Results Multiple analysis showed that low serum folic acid （ P = 0. 003 2, OR = 0. 149）, inadequate intake of folic acid （ P = 0.003 5, OR = 0.210） and fat （ P = 0.035 4, OR = 2. 632） were the risk factors of DVT. Conclusion Low serum folic acid level, inadequate intake of folic acid and fat increase the risk of DVT.
出处
《山东医药》
CAS
北大核心
2010年第12期20-22,共3页
Shandong Medical Journal
基金
河北省科学技术研究与发展指导计划课题(072761446)
