摘要
应用免疫组化SABC法，检测29例D_2期前列腺癌组织中雄激素受体的含量，并观察患者治疗前生活状态、骨转移程度、血浆前列腺特异性抗原、血浆睾酮和血红蛋白浓度等参数与患者预后之间的关系。结果发现：11例雄激素依赖性前列腺癌组中雄激素受体含量、血红蛋白、睾酮浓度分别为（51．0±14．8）％，（119．0±19．0）g/l，（9．8±7．9）ng／ml。而在18例雄激素非依赖性前列腺癌组中则分别为（32．2±118）％，（97．9±18．2）g/l，（4．0±6．4）ng／ml。雄激素受体含量、血红蛋白、睾酮浓度两组相比较，有显著性差异。（2）前列腺特异性抗原、生活状态、骨转移程度在雄激素依赖性前列腺癌组中分别为（122．8±70．5）ng／ml，1．5±0．7，1．4±0．5，在雄激素非依赖性前列腺癌组中则分别为（123．3±52．9）ng／ml，1．8±0.6，1．88±0.7，统计学分析两组没有差异（P＞0．05）。以上结果提示：D_2期前列腺癌组织中雄激素受体含量越高，治疗效果越好。雄激素受体含量的高低是预测晚期前列腺癌患者雄激素阻断治疗效果的良好指标。
Expression of androgen - receptor(AR) protein in 29 cases of stage D2 prostate carcinomatissues were determined by immunohistochemical SABC method, and relationship of prognosis andperformance status (PS), extent of disease of bone metastases (EOD), prostate specific antigen(PSA), testosterone (T) and Hemoglobin (Hb) concentration of untreated patients were alsoanalyzed. The results showed as below: content of AR in Pea tissues.concentration of Hb and level ofserum T in 11 cases of androgen - dependent prostate carcinotna (AD - Pea) were (51. 0 ±14. 8)%, (119. 0 ±19. 0) g/l, (9. 8 ±7. 9 ) ng/ml respeCtively, but in 18 cases of androgen -independent prostate carcinotna (AID - Pea),only (32. 2 ±11. 8) %, (97. 9 ±18. 2) g/l, (4. 0 ±6. 4) ng/ml respectively. Statistical analysis showed that the content of AR,Hb and serum T in AD - Peawere much higher than those in AID - Pea (P < 0. 01, P < 0. 01, P < 0. 05 respectively).concentration of serum PSA, PS,EOD in AD - Pca were (122. 8± 7. 5)ng/ml, 1. 5 ±0. 7, 1. 4 ±0. 5respecively, but in AID - Pca, being (123. 3 ±52. 9) ng/ml, 1. 8 ± 0. 6, 1. 88 ±0. 7 respecively.There was no significant difference between two groups (P >0. 05 ). In conclusion, the resultssuggested that androgen - receptor content might serve as a marker for the evalution of theprognosis of metastatic prostate carcinorna.
出处
《中国男科学杂志》
CAS
CSCD
1998年第4期193-196,共4页
Chinese Journal of Andrology
关键词
前列腺癌
受体
免疫组化
Prostate carcinoma
Receptor
Immunohistochethemical
