摘要
目的：探讨肿瘤高发区居民食管癌胃癌发病的相关因素及其特征。方法：对食管癌胃癌高发区３０岁以上自然人群１２３０人进行了五年前瞻性研究，按进入研究时的年龄暴露水平，用Ｍ－Ｈ法计算单一因素及多个因素的比值比，对相对危险进行估价。结果：发现上消化道病史（ＯＲ＝２．８４）、症状（ＯＲ＝４．６３），吸烟（ＯＲ＝３．４０）等因素与发病密切相关；而多吃豆类和／或豆制品（ＯＲ＝０．２３）以及蛋类（ＯＲ＝０．７９）等具有明显的保护作用。并发现这些因素之间的相互影响。结论：对生活在肿瘤高发区的４０岁以上成年人，特别是有上消化道病史和（或）症状，有癌症家族史且又吸烟者。
Objective: The aim of the study is to evaluate the characteristics of prevalence,risk factors of carcinomas of the esophagus and stomach.Methods: A prospective study on 1230 subjects over 30 years of age living in the high-incidence area of the esophagus and gastric cardia cancer (EGC) was conducted.Those who were allocated to different groups in terms of age and level of exposure entering upon the study,using the M-H methods to calculate the odds ratio of monofactor to multifactors for the evaluation of the relative risks.Results: The relative risk was found in those with the history and/or symptoms of diseases of the upper digestive tract (DUDT)(OR=4.27),and with cigarette smoking (OR= 3.40 ).An increased risk of cancers was observed when they had both factors.However,more intake of beans and/or bean made foods and eggs would have certain effects on the prevention of such cancers (OR= 0.23 ,0.79 respectively).Conclusion: The paper stresses the necessity of medical surveillance and health advice to target groups over 40 year old living in high-incidence areas,especially to those who are smoking and those who have a history /symptoms of DUDT and family history of cancer.
出处
《河南医学研究》
CAS
1998年第4期347-349,共3页
Henan Medical Research
关键词
食管癌
胃癌
危险因素
保护因素
前瞻性研究
esophagus carcinoma
stomach carcinoma
risk factors
protective factors
prospective study
