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铜绿假单胞菌主动外排系统与多重耐药性 被引量：8

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摘要 铜绿假单胞菌(PA)是假单胞菌中常见的院内感染条件致病菌,其对多种不同性质的抗生素高度耐药。复杂的主动排出系统在铜绿假单胞菌多重耐药性中起着极其重要的作用。通过检测已发现铜绿假单胞菌中的7种主动外排系统,包括MeXAB-OprM、MexCD-OprJ、MexEF-OprN、MexXY-OprM、MexJK-OprM、MexGHI-OpmD和MexVW-OprM。不同类型的外排系统在作用底物和调控机制等方面有着各自的特点。
作者 廖蕴惠 宋秀宇
机构地区 福建医科大学附属厦门第一医院检验科
出处 《国际检验医学杂志》 CAS 2010年第2期139-141,共3页 International Journal of Laboratory Medicine
关键词 假单胞菌 铜绿 抗药性 多药 主动外排
分类号 R378.991 [医药卫生—病原生物学]
  • 相关文献

参考文献11

  • 1Abdallah M,Jacqueline C,Sandrine A,et al. Antibiotic ef flux pumps in Gram-negative bacteria: the inhibitor re sponse strategy[J]. Journal of Antimicrobial Chemothera py,2007,59(6) :1223-1229.
  • 2Laura J V. Piddock, Clinically Relevant Chromosomally Encoded Multidrug Resistance Efflux Pumps in Bacteria [J].Clinical Microbiology Review, 2006,19 (2) : 382-402.
  • 3贾蓓,黄文祥,黄爱龙.细菌多药外排系统及其研究方法的进展(英文)[J].中国抗生素杂志,2007,32(4):203-210. 被引量：4
  • 4Yuji M, I.ily C, Virginia C, et al. nalD Encodes a Second Repressor of the mexAB oprM Muhidrug Efflux Operon of Pseudomonas aeruginosa[J]. Bacteriology, 2006, 188 (24) :8649-8654.
  • 5Katy J,Sylvie E,Thilo K,et al. Resistance and Virulence of Pseudomonas aeruginosa Clinical Strains Overprodu-cing the MexCD-OprJ Efflux Pump[J]. Antimicrob Agents,2008,52(7) :2455-2462.
  • 6Mara L. Sobel, Shadi Neshat, Keith Poole. Mutations in PA2491 (mexS) Promote MexT-Dependent mexEF-oprN Expression and Multidrug Resistance in a Clinical Strain of Pseudomonas aeruginosa[J]. Journal of Bacteriology, 2005,187(4): 1246 1253.
  • 7Didier H, Arno M, Karine B, et al. Relationship between Antibiotic Use and Incidence of MexXY-OprM Overprodueers among Clinical Isolates of Pseudomonas aeruginosa [J]. Antimicrob Agents,2008,52(3) :1173-1175.
  • 8John Quale, Simona Bratu,Jyoti Gupta, et al. Interplay of Efflux System, ampC, and oprD Expression in Carbapenem Resistance of Pseudomonas aeruginosa Clinical Isolates[J]. Antimicrob Agents Chemother, 2006,50(5): 1633-1641.
  • 9Giske C,Buaro L, Sundsfjord A, et al. Alterations of porin, pumps, and penicillin binding proteins in carbapenem resistant clinical isolates of Pseudomonas aeruginosa[J].Microb Drug Resist,2008,14(1):23-30.
  • 10Narcisa M, Youri G, Laetitia A, et al. A combined phenotypic and genotypie method for the detection of Mex efflux pumps in Pseudomonas aeruginosa[J]. Journal of Antimicrobial Chemotherapy, 2007,59 ( 1 ) : 378-386.

二级参考文献38

  • 1Murakami S,Nakashima R,Yamashita E,et al.Crystal structure of bacterial multidrug efflux transporter AcrB[J].Nature,2002,419(6907):587
  • 2Yu E W,Aires J R,Nikaido H.AcrB multidrug pump of Escherichia coli:composite substrate-binding cavity of exceptional flexibility generates its extremely wide substrate specificity[J].J Bacteriol,2003,185(19):5657
  • 3Yu E W,McDermott G,Zgurskaya H I,et al.Structural basis of multiple drug-binding capacity of the AcrB multidrug efflux pump[J].Science,2003,300(5621):976
  • 4Poole K,Krebes K,McNally C,et al.Multiple antibiotic resistance in Pseudomonas aeruginosa:evidence for involvement of an efflux operon[J].J Bacteriol,1993,175(22):7363
  • 5Poole K,Gotoh N,Tsujimoto H,et al.Overexpression of the meχC-meχD-oprJ effux operon in nfχB-type multidrug resistant strains[J].Mol Microbiol,1996,21(4):713
  • 6Kohler T,Michea-Hamzehpour T,Henze U,et al.Characterization of MexE-MexF-OprN,a positively regulated multidrug efflux system of Pseudomonas aeruginosa[J].Mol Microbiol,1997,23(2):345
  • 7Mine T,Morita Y,Kataoka A,et al.Expression in Escherichia coli of a new multidrug efflux pump,MexXY,from Pseudomonas aeruginosa[J].Antimicrob Agents Chemother,1999,43(2):415
  • 8Chuanchuen R,Narasaki C T,Schweizer H P.The MexJK efflux pump of Pseudomonas aeruginosa requires OprM for antibiotic efflux but not for efflux of triclosan[J].J Bacteriol,2002,184(18):5036
  • 9Aendekerk S,Ghysels B,Cornelis P,et al.Characterization of a new efflux pump,MexGHI-OpmD,from Pseudomonas aeruginosa that confers resistance to vanadium[J].Microbiology,2002,148(Pt8),2371
  • 10Li Y,Mima T,Komori Y,et al.A new member of the tripartite multidrug efflux pumps,MexVW-OprM,in Pseudomonas aeruginosa[J].J Antimicrob Chemother,2003,52(4):572

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引证文献8

二级引证文献41

国际检验医学杂志
2010年 第2期

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