摘要
目的探讨铜绿假单胞菌的耐药性及其变迁。方法临床分离的铜绿假单胞菌1 731株,用23种抗生素进行药敏试验。结果 1 731株铜绿假单胞菌对氨苄西林、头孢唑林、头孢呋辛的耐药率大于90%,其次为复方新诺明83.2%。耐药率大于70%的有奈替米星75.2%、氧氟沙星70.4%、四环素74.1%、氯霉素72.0%,耐药率小于30%的有头孢哌酮/舒巴坦、头胞吡肟、亚胺培南、头孢他啶。12年间耐药性有普遍增高的趋势,2004年至2007年部分有所减缓,但2008年又有所回升。结论铜绿假单胞菌已成为临床最常见的致病菌之一,它的耐药及多重耐药已非常严重。为提高抗菌治疗效果应连续监测本地区的抗菌药物耐药情况,根据药敏结果合理选用抗菌药物。
Objective To explore the drug resistance diversity of pseufomonsd aeruginosa. Methods We did sensitivity experiments by 23 antibiotic of 1731 pseudomonad aeruginosa identified from clinic during 1997 to 2008. Results In 1 731 pseudomonad aeruginosa, the samples were main from phlegm, accounted for 58.5 %. the second from secretion accounted for 24.7 %. The drug resistance of pseudomonad aeruginosa for ampicillin, cefazolin and cefuroxime sodium were all higher than 90%, the second were trimethoprim/sulfamethoxazole 83.2%. The antibacterial medicines of drug resistance higher than 70% were netilmicn（75. 2% ）,oftoxacin（70.4% ）,tetracycline（74.1%）,choramphenicol（72.0%）. The antibacterial medicines of drug resistance lower than 30 % were Cefoperazone/Sulbactam, cefepime,imipenem, ceftazidme. In 12 years, the drug resistance diversity had enhanced prevalent trend. The enhanced speed of proportion drug was slow in 2004-2007 ,but it was fast again in 08 year. Conclusion The pseudomonad aeruginosa have become one of the most clinical routine nosogenetic germs. It showed single and anti muhiresistance of antibiotics seriously. In order to improve antibacterial treating effect, we should inspect the drug resistance continuously in our area. We could select rationally antibacterial medicine according to the result of medicine sensitivity experiments.
出处
《国际检验医学杂志》
CAS
2010年第2期133-134,136,共3页
International Journal of Laboratory Medicine
关键词
假单胞菌
铜绿
抗菌药
抗药性
细菌
河南
Pseudomonas aeruginosa
Anti Bacterial Agents
Drug Resistance, Bacterial
HENAN
