摘要
Quality standardization of complementary medicine is fundamental for industry and practice as it underpins the quality,safety and efficacy of Chinese herbal medicines.Current herbal standardizations are often based on the quantitative analysis of a single compound,which may not reflect the total characteristic,bioactive and toxic nature of the herbs or products.Therefore,there is a need to establish an internationally recognized methodology for quality standardization of Chinese herbal medicines.The analytical methods reviewed in this article are pharmacognosy,TLC,HPLC,LCMS,CE and chemo-metrics.This article also covers the developments and applications of these methods in quality standardization.Recent advances show that a combination of these methods creates an overall chemical profile of each herb.This is supported by results reviewed in this article and obtained in our laboratory tests on medicinal herbs including Hypericum perforatum,Morinda officinalis and Centella asiatica.Significant variations in active components have been observed between herbal samples and products.It is proposed that the identification of active components,pharmacological activities and eventual clinical applications are required for a comprehensive quality standardization system.Our findings indicate that the combination of various chromatographic and chemometric methods will advance the methodology of quality standardization and enhance the overall confidence in herbal medicine for the health practitioner and the public.
Quality standardization of complementary medicine is fundamental for industry and practice as it underpins the quality, safety and efficacy of Chinese herbal medicines. Current herbal standardizations are often based on the quantitative analysis of a single compound, which may not reflect the total characteristic, bioactive and toxic nature of the herbs or products. Therefore, there is a need to establish an internationally recognized methodology for quality standardization of Chinese herbal medicines.The analytical methods reviewed in this ar- ticle are pharmacognosy, TLC, HPLC, LCMS, CE and chemo-metrics. This article also covers the developments and applications of these methods in quality standardization. Recent advances show that a combination of these methods creates an overall chemical profile of each herb. This is supported by results reviewed in this article and obtained in our laboratory tests on medicinal herbs including Hypericum perforatum, Morinda officinalis and Centella asiatica. Significant variations in active components have been observed between herbal samples and products. It is proposed that the identification of active components, pharmacological activities and eventual clinical applications are required for a comprehensive quality standardization system. Our findings indicate that the combination of various chromatographic and chemometric methods will advance the methodology of quality standardization and enhance the overall confidence in herbal medicine for the health practitioner and the public.
出处
《世界科学技术-中医药现代化》
2010年第1期99-106,共8页
Modernization of Traditional Chinese Medicine and Materia Medica-World Science and Technology
基金
supported by the International Science Linkages Australia China Special Found 2007,CH0701667
established under the Australian Government's innovationstatement,Backing Australia's Ability and the University of Sydney International Program Development Fund (IDPF,2008)
the China Australia Special Fund from the China National Science Fund Commission(Quality Standardisation,anti-inflammation and anti-depressant activities of Hypericum species and Morinda Officinalis,Yang Dp,2007)
关键词
毛细管
草药
合理用药
中医
Capillary electrophoresis
Chemo-metrics
Herbal medicines
High performance liquid chromatography
Liquid chromatography mass spectrometry
Pharmacognosy
Quality standardization
Thin layer chromatography.
