摘要
为了解老年人血脂水平与载脂蛋白E基因多态性的关系．并探讨载脂蛋白E等位基因对老年人血脂水平的内在影响，利用PCR－RFLP法测定了载脂蛋白E基因型，并用酶学方法对其血脂水平进行了测定。结果发现存在五种不同基因型；与携有ε3等位基因的人群相比，携有ε1等位基因的人群倾向具有较高的总胆固醇和低密度脂蛋白胆固醇水平以及较低的甘油三酯水平，而携有ε2等位基因的人群则有较低的低密度脂蛋白胆固醇水平以及较高的甘油三酯水平．但无统计学差异。提示载脂蛋白E等位基因影响老年人的血脂水平，但可能不如成年人显著和明显。
Aim To analyse the internal relation between the serum lipid levels and apolipoprotein E genotypes in the aged.Methods The serum lipid levels(TC,TG,LDLC and HDLC)and the apolipoprotein E (apo E)geno-types in 106 the aged were determined with enzymolo-gy and PCR-RFLP respectively.Results There were three alleles of apo E and five different genotypes in 106 the aged.The aged with ε4allele showed higher TC,LDLC and lower TG levels as well as the aged with ε2 allele showed lower LDLC and higher TG levels than the aged with ε3 allele.Conclusion The alleles of apo E have a certain ef-fect on the serum lipid levels in the aged,but the ef-fect may not be as obvious and strong in the aged as in adults.
出处
《中国动脉硬化杂志》
CAS
CSCD
1998年第4期314-316,共3页
Chinese Journal of Arteriosclerosis
基金
天津市自然科学基金!973608611
关键词
载脂蛋白E
基因
老年人
血脂
Apolipoprotein E
Aged
Allele
Serum lipid
