摘要
目的:了解抗病毒药致不良反应发生的特点及一般规律。方法:检索维普中文科技期刊数据库及中国知网(CNKI)中文期刊全文数据库,收集1999～2009年国内医药学术期刊报道的符合要求的抗病毒药致不良反应文献52篇,共523例,并进行统计、分析。结果:抗病毒药致不良反应中,静脉滴注给药比例最高(82.79%);临床表现复杂多样,主要表现为变态反应、消化系统损害、循环系统损害、泌尿系统损害等,其中,阿昔洛韦以泌尿系统损害最为突出(73例)。结论:临床应重视抗病毒药致不良反应,尤其是过敏性休克,坚持合理用药。
OBJECTIVE： To analyze the characteristics and regularity of adverse drug reactions induced by antiviral drugs. METHODS： 52 literatures on the antiviral drugs-induced ADR were retrieved from VIP database and CNKI from 1999 to 2009. 523 cases in literatures were analyzed statistically. RESULTS： 82.79% of ADR cases were induced by via intravenous drip administration. Various clinical manifestation of ADR cases mainly appeared as allergic reactions, injury of digestive, circulatory system and urinary system, etc. 73 ADR cases were induced by acyclovir mainly appeared as injury of urinary system. CONCLUSION： Great importance should be attached to rational use of drugs and antiviral drugs-induced ADR, especially allergic shock.
出处
《中国药房》
CAS
CSCD
北大核心
2010年第10期930-932,共3页
China Pharmacy
关键词
抗病毒药
不良反应
文献分析
Antiviral drugs
Adverse drug reaction
Literature analysis
