摘要
目的:了解氟喹诺酮类药致不良反应(ADR)发生的特点及规律。方法:通过检索1994年1月～2009年6月中国医院数字图书馆(CHKD)期刊全文数据库收载的中文医药卫生期刊,共收集到有效的有关氟喹诺酮类药致不良反应文献231篇,共308例,并进行统计、分析。结果:308例氟喹诺酮类药致ADR与患者性别、年龄无显著相关性;致ADR的给药途径以静脉滴注为主,占76.62%;用药后2～5d内出现ADR的比例较大,占33.44%;左氧氟沙星致ADR的例数最多,占19.81%;ADR累及器官或系统以中枢神经系统损害较常见,占30.43%,其次是皮肤及其附件损害,占20.58%,严重者可出现过敏性休克死亡(6例)。结论:临床应高度重视氟喹诺酮类药致ADR的监测,合理选用,确保用药的安全、有效。
OBJECTIVE： To investigate the characteristics and regularity of adverse drug reactions （ADR） induced by fluoroquinolones. METHODS： 308 fluoroquinolones-induced ADR cases in 231 literatures were collected from domestic medical journals recorded in CHKD from Jan.1994 to Jun.2009 and analyzed statistically. RESULTS： There was no marked relation between the ADR induced by fluoroquinolones and the gender or age of the patients. 76.62% of ADR cases were mainly caused via intravenous drop infusion. 33.44% of ADR occurred within 2-5 days after medication, leading the first place in term of ADR incidence was levofloxacin （19.81%）. ADR mainly appeared as injury of central nervous system （30.43 % ）, followed by lesion of skin and appendants （20.58%）. 6 severe ADR induced shock and death. CONCLUSION： Great importance should be attached to monitoring of ADR induced by fluoroquinolones and rational use of drug to guarantee safety and effectiveness of medication.
出处
《中国药房》
CAS
CSCD
北大核心
2010年第10期928-930,共3页
China Pharmacy
关键词
氟喹诺酮类药
不良反应
分析
Fluoroquinolones
Adverse drug reaction
Analysis
