摘要
目的探讨Graves病(GD)患者血液学异常的发生率及其相关因素。方法2007年2月—2009年2月本院内分泌科新诊断GD患者126例,检测患者血清甲状腺激素、甲状腺自身抗体水平及血常规,对其血液学异常的发生率、临床特点及相关因素进行分析。结果新诊断126例GD患者中,白细胞减少24例(19.0%),其中中性粒细胞减少9例(7.1%);贫血11例(8.7%);血小板减少14例(11.1%);共33例(26.2%)患者发生血液学异常,其中6例白细胞减少合并贫血,7例白细胞减少合并血小板减少。白细胞计数与患者年龄及游离甲状腺原氨酸(FT3)水平呈负相关(P<0.05);中性粒细胞计数与三碘甲状腺原氨酸(TT3)、FT3、甲状腺素(TT4)、游离甲状腺素(FT4)呈负相关(P<0.01);血红蛋白及血小板计数仅与患者年龄呈负相关(P<0.05)。结论GD患者血液学异常的发生率较高,白细胞减少与甲状腺功能亢进症的程度有关;建议行药物治疗之前,需对GD患者行血常规检查,尤其是重症、高龄患者。
Objective To investigate the prevalence and the possible risk factors of hematological abnormalities in patients with Graves＇ disease（GD）.Methods One hundred twenty-six patients were newly diagnosed as GD in our department of endocrinoliogy from Feb.2007 to Feb.2009.Serum thyroid hormones,thyroid autoantibodies levels and routine blood test were detected to analyze the incidence of abnormal hematology,clinical features and its related factors.Results Among 126 newly diagnosed GD patients,24 presented with leucopenia （19.0%）,9 with neutropenia （7.1%）,11 with anemia （8.73%）,14 with thrombocytopenia （11.1%）.There were altogether 33 patients presenting with abnormal hematology （4.76%）,including 6 leucopenia complicated by anemia,7 by thrombocytopenia.White blood cell counts were negatively correlated with age,free thyroxin （FT3）level （P0.05）,neutrophil counts with triiodothyronine （TT3）,FT3,thyroxine （TT4）,free thyroxine （FT4） （P0.01）,and hemoglobin and platelet counts with only age （P0.05）.Conclusion The incidence of hematological abnormalities is relatively high,and leucopenia is related to the degree of hyperthyroidism.It is suggested that blood routine examinations should be conducted in GD patients,especially in severe,elderly patients before drug treatment.
出处
《中国全科医学》
CAS
CSCD
北大核心
2010年第8期855-856,859,共3页
Chinese General Practice
