摘要
肠道病毒71型（enterovirus 71, EV71）是人类肠道病毒的一种，近30年来，EV71感染在亚太地区广泛流行，是手足口病（HFMD）重症病例的主要病原体。EV71感染引起的重症HFMD病情进展迅速，可表现为中枢神经系统和呼吸系统受累，其发病机制目前尚不十分清楚。研究认为病毒首先通过神经通路侵犯中枢神经系统，导致中枢神经系统的并发症，严重的病例进一步发展为肺水肿、肺出血。研究重症EV71感染的临床特征和发病机制从而采取积极有效的措施阻断其并发症的发生具有重要意义。
Enterovirus 71 （EV71 ）, a member of human enterovirus family, was first isolated from faeces of a central nervous system infected infant in 1969. In recent 30 years,EV71 outbreaks every 2-3 years in the Asia-Pacific regions,and is the main pathogen causing severe hand-foot-mouth disease（HFMD）. Severe HFMD caused by EV71 involves in central nervous system and respiratory system disorder. In general, EV71 associated complication is related to the viral invasion of central nervous system, leads to pulmonary edema or pulmonary hemornage. It is of great significance to study the clinical features and pathogenesis of EV71 infection, and then take positive and effective measures to block the occurrence of its complications.
出处
《国际儿科学杂志》
2010年第2期199-202,共4页
International Journal of Pediatrics
