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拉莫三嗪治疗儿童癫痫的临床研究 被引量:5

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摘要 目的:探讨拉莫三嗪治疗儿童癫痫的临床效果。方法:选择70例癫痫患儿,随机分为观察组和对照组,对照组常规治疗,观察组在常规治疗的基础上加用拉莫三嗪,比较两组的疗效和不良反应。结果:观察组控制11例,显效14例,有效8例,总有效率为94.3%;对照组控制6例,显效10例,有效11例,总有效率为77.1%;两组比较,差异有统计学意义(P<0.05),观察组总体治疗效果要优于对照组。观察组不良反应发生率为17.1%,对照组为11.4%,组间差异无统计学意义(P>0.05)。结论:拉莫三嗪治疗儿童癫痫的疗效是肯定的,值得在临床推广应用。
作者 王广晖
出处 《中国医药导报》 CAS 2010年第9期53-54,共2页 China Medical Herald
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  • 1张振馨,潘映辐,费亚新,姬长莲,刘秀琴,陈葵,徐敬琴,周立春,李舜伟.拉莫三嗪作为添加药物治疗顽固性癫痫的自身对照研究[J].中华神经科杂志,1996,29(1):33-37. 被引量:11
  • 2[1]Dulac O,N'Guyen T.The Lennox-Gastaut syndrome[J].Epilepsia,1993,34(suppl 7):S7~17.
  • 3[2]Hauser WA.The prevalence and incidence of convulsive disorders in children[J].Epilepsia,1994,35(suppl 2):S1~6.
  • 4[3]Commission on Classification and Terminology of the International League Against Epilepey.Proposal for Revised Classification of Epilepsies and Epileptic Syndromes[ J].Epilepsia,1989,30:389~399.
  • 5[4]Duchowny M,Pellock JM,Graf WD,et al.Lamotrigine addon therapy for partial seizures in children[J].Neurology,1999,53(8):1 724.
  • 6[5]Schlumberger E,Chavez F,Palacios L,et al.Lamotrigine in treatment of 120 children with epilepsy[J].Epilepsia,1994,35:359~367.
  • 7[6]Besag FMC,Wallace SJ,Dulac O,et al.Lamotrigine for the treatment of epilepsy in childhood[J].J Pediat,1995,127:991~997.
  • 8Buchanan N.lamotrigine:clinical experience in 93 patients with epilepsy[J].Acta Neuro Scand,1995,92(1):28~33.
  • 9Binnie CD.The efficacy of lamotrigine[J].Rev Contemp Pharmacother,1994,5:115~ 119.
  • 10Aldenkamp A P,Baker G.A Systematic review of the effects of lamotrigine on cognitive function and quality of life[J].Epilepsy Behavior,2001,2(2):85~91.

共引文献33

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  • 1彭静玉,李光来.拉莫三嗪对脑缺血的神经保护作用[J].国外医学(脑血管疾病分册),2005,13(11):843-846. 被引量:7
  • 2林苗,朱珠.新型抗癫痫药的安全性评价[J].药物不良反应杂志,2006,8(2):81-87. 被引量:19
  • 3王萍,任榕娜.抗癫痫药物的毒副作用[J].国际内科学杂志,2007,34(2):91-94. 被引量:33
  • 4Noriaki NAKAI,Norito KATOH.Value of a lymphocyte transformation test for diagnosis of maculopapular and erythema multiforme type drug eruption due to lamotrigine: Three case reports[J]. The Journal of Dermatology . 2012 (12)
  • 5Casetta I, Pugliatti M, Faggioli R, et al. Incidence of childhood and adolescence epilepsy: a community-based prospective study in the province of Ferrara and in Copparo, Italy, 1996-2005 [J]. Eur J Neurol, 2012, 19 (2): 312 316.
  • 6Gu L,Liang B,Chen Q, et al. Prevalence of epilepsy in the people's republic of China:a systematic reviewEJ]. Epilepsy Res,2013,105(1/2) : 195-205.
  • 7Glauser T,Ben-Menachem E, Bourgeois B, et al. Upda- ted ILAE evidence review of antiepileptic drug efficacy and effectiveness as initial monotherapy for epileptic seizures and syndromes EJ]. Epilepsia, 2013, 54 (3): 551-563.
  • 8Nunes V D, Sawyer L, Neilson J, et al. Diagnosis and management of the epilepsies in adults and children: summary of updated NICE guidance[J]. BMJ, 2012, 344: e281.
  • 9Duehowny M,Pellock J M, Graf W D, et al. A placebo- controlled trial of lamotrigine add-on therapy for partial seizures in children[J]. Neurology, 1999,53 (8) : 1724- 1731.
  • 10Holmes G L, Frank L M, Sheth R D. et al. Lamotrigi- ne monotherapy for newly diagnosed typical absence seizures in children[J]. Epilepsy Res, 2008,82 ( 2/3 ) 124-152.

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