摘要
【目的】探讨小剂量红霉素对极低出生体重儿（very low birth weight infants，VLBWI）喂养不耐受及生长发育的影响。【方法】将68例VLBWI随机分为治疗组（35例），对照组（33例）。两组患儿均以常规护理和治疗，治疗组在此基础上加用小剂量红霉素治疗[5mg／（kg·d），疗程7～10d]；监测喂养不耐受及生长发育相关指标。【结果】治疗组胃残留量、腹胀消失时间、达全量胃肠喂养时间均明显低于对照组（P〈0．01）；治疗组3、6个月体重、身长及其赶上生长分别高于对照组（P〈0．05）。治疗过程中无不良反应发生。【结论】小剂量红霉素可以降低极低VLBWI喂养不耐受的发生率；同时对其早期体格发育有明显的促进作用，值得临床推广应用。
[Objective] To explore the effects of low-dose erythromycin on feeding intolerance and growth and development in very low birth weight infants. [Methods] 68 very low birth weight infants were randomly assigned into 2 groups（the 35 infants as therapy group, another 33 infants as control group）. All infants in 2 groups were given general care and treatment. Low-dose erythromycin was administered to infants at the same time in therapy group[5mg/（kg · d）,lasted 7-10 d] ;The parameters of feeding intolerance and growth and development were all recorded in two groups. [Results] The waste milk volume was significantly lower in low-dose erythromycin-treated infants than that of control group（P〈 0.01）. In therapy group, the time for both disappearance of abdominal bloat and achievement of full gastrointestinal nutrition were significantly shortened eompared with those of control group too（P〈0.01）. During 3 to 6 months after birth ,the weight, height as well as catch-up growth of infants in therapy group were obviously higher than those in control group（P 〈0.05）. No adverse effect was associated with low-dose erythromycin treatment. [Conclusions] Low-dose erythromycin can improve the feeding intolerance of very low birth weight infants, facilitate their early growth and development meanwhile. It is deserved to be introduced in clinical application extensively.
出处
《中国儿童保健杂志》
CAS
2010年第3期240-242,共3页
Chinese Journal of Child Health Care
关键词
极低出生体重
喂养不耐受
红霉素
生长发育
婴儿
very low birth weight
feeding intolerance
erythromycin
growth and development
infant
