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Notch信号传导在淋巴细胞发育中的作用 被引量：1

Role of Notch signal transduction in the development of lymphocyte
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摘要 Notch信号旁路在调节造血系统的发育选择、分化和功能方面起着关键性的作用,尤其在胚胎发育时期,其调节造血干细胞的产生并影响造血祖细胞的发育。本文就Notch信号对于T细胞系的定性和早期胸腺细胞的发育的作用作一综述。
作者 杜宏 于力
机构地区 解放军总医院血液科
出处 《军医进修学院学报》 CAS 2010年第3期294-296,共3页 Academic Journal of Pla Postgraduate Medical School
基金 首都医学发展科研基金(2007-2040)~~
关键词 受体 Notch 信号传导 T淋巴细胞
分类号 R329.2 [医药卫生—人体解剖和组织胚胎学]
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参考文献22

  • 1Artavanis-Tsakonas S, Rand MD, Lake RJ. Notch signaling : cell fate control and signal integration in development [ J ] . Science, 1999, 284 : 770-776.
  • 2Stier S, Cheng T, Dombkowski D, et al. Notchl activation increases hematopoietic stem cell serf-renewal in vivo and favors lymphoid over myeloid lineage outcome [ J ]. Blood, 2002, 99 ( 7 ) : 2369-2378.
  • 3Varnum-Finney B, Brashem-Stein C, Bernstein ID. Combined effects of Notch signaling and cytokines induce a multiple log increase in precursors with lymphoid and myeloid reconstituting ability [ J ] . Blood, 2003, 101 : 1784-1789.
  • 4Izon DJ, Aster JC, He Y, et al. Deltexl redirects lymphoid progenitors to the B cell lineage by antagonizing Notchl [J]. Immunity, 2002, 16 : 231-243.
  • 5Allman D, Punt JA, Izon DJ, et al. An invitation to T and more : notch signaling in lymphopoiesis [ J ] . Cell, 2002, 109 : S1-S11.
  • 6Wolfer A, Bakker T, Wilson A, et al. Inactivation of Notchl in immature thymocytes does not perturb CD4 or CD8 T cell development [ J ] . Nat Immunol, 2001, 2 : 235-241.
  • 7Guidos CJ. Notch signaling in lymphocyte development[J]. Semin Immunol, 2002, 4 : 395-404.
  • 8Saito T, Chiba S, Ichikawa M, et al. Notch2 is preferentially expressed in mature B cells and indispensable for marginal zone B lineage development [ J ] . Immunity, 2003, 18 : 675-685.
  • 9Huang EY, Gallegos AM, Richards SM, et al. Surface expression of Notchl on thymocytes : correlation with the double-negative to double-positive transition [ J ] . J Immunol, 2003, 171 : 2296- 2304.
  • 10Fowlkes BJ, Robey EA. A reassessment of the effect of activated Notchl on CD4 and CD8 T cell development [ J ] . J Immunol, 2002, 169 : 1817-1821.

同被引文献32

  • 1Schmierer B,Hill CS.TGFbeta-SMAD signal transduction:molecular specificity and functional flexibility[J].Nat Rev Mol Cell Biol,2007,8 (12):970-982.
  • 2Outram SV,Chen D,Umukoro C.BMP signals:Mediated by stroma or thymocytes?[J].Cell Cycle,2014,13 (4):505-506.
  • 3Nishinakamura R,Sakaguchi M.BMP signaling and its modifiers in kidney development[J].Pediatr Nephrol,2014,29 (4):681-686.
  • 4Li Z,Chen YG.Functions of BMP signaling in embryonic stem cell fate determination[J].Exp Cell Res,2013,319 (2):113-119.
  • 5Sagorny K,Chapellier M,Laperrousaz B,et al.BMP and cancer:the Yin and Yang of stem cells[J].Med Sci (Paris),2012,28(4):416-422.
  • 6Schwanbeck R,Martini S,Bernoth K,et al.The notch signaling pathway:molecular basis of cell context dependency[J].Eur J Cell Biol,2011,90 (6/7):572-581.
  • 7Yang Q, Bell J J, Bhandoola A. T-cell lineage determination [ J ] . Immunol Rev, 2010, 238 ( 1 ) : 12-22.
  • 8Kopf J,Paarmann P,Hiepen C,et al.BMP growth factor signaling in a biomechanical context[J/OL].http://onlinelibrary.wiley.com/doi/10.1002/biof.1137/abstract ; jsessionid=DA72C134EC4324B35F2DA1E2D9CE2F5E.f02t01.
  • 9Wagner DO,Sieber C,Bhushan R,et al.BMPs:from bone to body morphogenetic proteins[J].Sci Signal,2010,3 (107):mr1.
  • 10Moustakas A,Miyazawa K,Cunha S I,et al.TGF-?? Signaling in Physiological and Pathological Angiogenesis[M].Japan:Springer,2013:323-348.

引证文献1

军医进修学院学报
2010年 第3期

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