摘要
目的观察睾酮对人脐静脉内皮细胞表达转化生长因子-β1和血红素加氧酶-1的影响。方法用ELISA法观察睾酮对内皮细胞表达TGF-β1和HO-1的影响。结果睾酮在生理浓度(3.0×10-8mol/L)或接近生理浓度下均能促进内皮细胞表达TGF-β1和HO-1的量。两者的表达呈时间(当t=24h达到最理想的分泌量)、浓度依赖关系。结论生理浓度睾酮或接近生理浓度的睾酮有一定的细胞保护作用。
Objective To investigate the effect of testosterone on expression of transforming growth factor-β1（TGF-β1） and hemeoxygenase-1（HO-1）in endothelial cells of human umbilical vein.Methods Effect of testosterone on expression of TGF-β1 and HO-1 in endothelial cells of human umbilical vein was detected by ELISA.Results Testosterone at a physiological concentration of 3.0×10-8mol/L or at an approximately physiological concentration promoted the expression of TGF-β1 and HO-1 in endothelial cells of human umbilical vein in a time-and concentration-dependent manner.Conclusion Testosterone at a physiological concentration or at an approximately physiological concentration promotes the expression of TGF-β1 and HO-1 in endothelial cells of human umbilical vein.
出处
《军医进修学院学报》
CAS
2010年第3期268-269,共2页
Academic Journal of Pla Postgraduate Medical School
基金
全军医药卫生"十一.五"计划科技攻关课题(06G144)~~
