摘要
目的探讨替考拉宁对前列腺炎(BP)大鼠的治疗效果。方法分别对正常前列腺(NP)、BP的SD雄性大鼠由尾静脉注射1次/d替考拉宁(100mg/kg)共5d。分离大鼠血清和前列腺,以琼脂扩散法及最低抑菌浓度法(MIC)检测血清抗生素活性,对前列腺进行病原菌的分离培养与计数;治疗结束后1～5周,分离BP组大鼠的前列腺,进行病理学检查。结果BP组大鼠前列腺组织内病原菌数量随给药时间延长而逐渐减少,在给药第5天后83.3%的大鼠前列腺组织已不能检出病原菌。各组大鼠给药后10～150min其血清及前列腺组织内均可检出明显的抗生素活性。组织病理学检查可见BP组大鼠前列腺组织表现出明显的渗出、白细胞浸润。随给药时间延长以及前列腺病原菌数量的减少或消失,BP组大鼠前列腺的组织炎性病理学改变可明显缓解。结论静脉注射替考拉宁能够进入大鼠革兰阳性细菌性炎症前列腺组织内,能够有效地杀灭前列腺组织内的敏感细菌,以促进前列腺组织的炎症反应缓解及损伤组织的修复。
Objective To study the therapeutic effect of teicoplanin on prostatitis（BP） of rats.Methods Male SD rats with normal prostate（NP） and BP were injected with teicoplanin（100mg/kg） through the tail vein, once a day for 5 days.Serum and prostate were isolated, respectively, from the rats.Serum antibiotic activities were detected by agar diffusion and minimal bacteriostatic concentration（MIC）.Pathogenic bacteria, isolated from the prostate, were cultured and calculated.After 1-5 weeks of treatment with teicoplanin, prostate was isolated from the rats with BP for pathological examination.Results In the first 4 days after treatment with teicoplanin, the number of bacteria was decreased in samples from the prostate of rats treated with teicoplanin.After 5 days of treatment with teicoplanin, no bacteria could be detected in 83.3% of rat prostates.Antibiotic activities were detected in serum and prostates 10-150 min after treatment with antibiotics.Pathologic tests showed obvious exudation and leukocyte invasion in prostate tissues of BP rats.Teicoplanin treatment and the reduced bacteria obviously alleviated the inflammation in prostates of BP rats.Conclusion Intravenous injected teicoplanin can penetrate the prostate of BP rats.Since the antibiotic concentration may be equal to or higher in rat prostate tissues than in serum, susceptive bacteria in prostates can be killed, and inflammation caused by Grampositive bacteria can be alleviated and damaged prostate tissues can be effectively repaired.
出处
《军医进修学院学报》
CAS
2010年第3期265-267,283,共4页
Academic Journal of Pla Postgraduate Medical School
基金
军队"十一.五"科技攻关项目(06G031)~~
