摘要
1例91岁男性大疱类天疱疮患者长期口服醋酸泼尼松片5 mg/d。因癫痫发作给予丙戊酸钠缓释片250 mg,1次/d口服。5个月后剂量加至500 mg,1次/d口服。2周后患者排成形柏油便3次。实验室检查示Hb 84 g/L,PLT 45×109/L;粪潜血(+)。丙戊酸钠缓释片遂减量至125 mg,1次/d,并行对症治疗。7 d后血小板恢复正常,上消化道出血停止。
A 91-year-old man with bullous pemphigoid took long-term oral prednisone acetate tablets 5 mg/d.He received sustained-release sodium valproate 250 mg once daily for epileptic seizure.Five months later,the dosage was increased to 500 mg once daily.After 2 weeks,the patient experienced 3 tarry stools.Laboratory tests revealed the following levels： Hb 84 g/L,PLT 45×109/L;stool occult blood（＋）.Sustained-release sodium valproate tablets was decreased to 125 mg once daily and symptomatic therapy was given.Seven days later,his platelet count normalized and upper gastrointestinal haemorrhage subsided.
出处
《药物不良反应杂志》
2009年第6期434-435,共2页
Adverse Drug Reactions Journal
关键词
丙戊酸钠缓释片
不良反应
血小板减少
上消化道出血
sustained-release sodium valproate tablets
adverse reactions
thrombocytopenia
upper gastrointestinal haemorrhage
