摘要
用高碘酸钠活化低抗凝活性肝素（ＬＡＡＨ）修饰猪血红细胞Ｃｕ，Ｚｎ－ＳＯＤ，制成ＬＡＡＨ（ＩＯ４）－ＳＯＤ。给兔１次静注修饰ＳＯＤ１００００ｕ／ｋｇ，药－时数据符合双室模型，经计算机求出药代动力学参数。修饰ＳＯＤ的分布半衰期和消除半衰期比修饰前延长至１．９和８．６倍。小鼠腹腔注射修饰ＳＯＤ２００ｕ／ｇ，酶活性主要分布于肝和肾，并能通过血脑屏障。
Swine erythrocyte Cu, Zn superoxide dismutase(SOD) was modified with low anticoagulant activity heparin(LAAH) which had been activated by sodium periodate to form LAAH(IO 4) SOD. After a single intravenous injection of the modified SOD (1000u/kg) into rabbits, the concentration time data conformed to the two compartment model, and the pharmacokinetic parameters were calculated. The distribution half-life and the elimination half time of the modified SOD increased 1.9 and 8.6 fold compared with the free SOD. After intraperitoneal injection of the modified SOD (200u/g) into mice, SOD activity was mainly found in the liver and kidney, and the modified SOD could pass through the blood-brain barrier.
出处
《山东医科大学学报》
1998年第4期343-345,共3页
Acta Academiae Medicinae Shandong
基金
山东省科委科研基金
关键词
SOD
肝素
化学修饰
药代动力学
Superoxide dismutase
Heparin
Chemical modification
Pharmacokinetics
