摘要
灌胃给予Ｌ６１５白血病患鼠狼毒大戟水提物３．０ｇ／ｋｇ（相当生药）７ｄ，小鼠Ｔ淋巴白血病细胞增殖受到了较强地抑制（Ｐ＜０．０２），显著增加了由于Ｌ６１５白血病细胞攻击所致的肝中谷胱甘肽过氧化酶（ＧＳＨ－Ｐｘ）和超氧化物歧化酶活力（ＳＯＤ）下降（Ｐ＜０．０１，Ｐ＜０．００１）。但狼毒大戟１．８ｇ／ｋｇ水提物对白血病细胞增殖的抑制作用较弱，对ＧＳＨ－Ｐｘ与ＳＯＤ活力的恢复无效，提示其抗Ｌ６１５白血病的有效剂量应大于１．８ｇ／ｋｇ。
The water extract of chinese herbal medicine,euphorbia fischriana stead (LS), showed strong inhibition of L 615 mice T lymphocyte cell proliferation by administration intragasrtrically of 3g/(kg.d) LS(equal to raw material) for 7 days ( P < 0.02 ).For attacking of L 615 leukemia cell,the GSH Px and SOD activation were decreased,and recovered significantly after administration LS ( P <0.01, P <0.001).The same results havent been observed when tested with the extract of 1.8g/(kg.d). The effective dosage against leukemia should be over 1.8g/(kg.d).
出处
《山东医科大学学报》
1998年第4期289-290,共2页
Acta Academiae Medicinae Shandong
关键词
狼毒大戟
白血病
谷胱甘肽
过氧化酶
SOD
Euphorbia fischeriana stead
Leukemia
Experimental
Glutathione peroxidase
Superoxide dismutase
