摘要
目的观察经皮动脉灌注化疗药物及ＬＡＫ／ＩＬ２治疗晚期贲门癌疗效。方法采用经皮穿刺胃左动脉插管灌注健康人外周血ＬＡＫ细胞１×１０９／１００ｍｌ及ＩＬ２３０万Ｕ，化疗药物为表阿霉素３０ｍｇ、卡铂３００ｍｇ、长春地辛（西艾克）４ｍｇ或５ＦＵ１０００ｍｇ，每３～４周１次，２次为１疗程。结果经病理学确诊的共７８例晚期贲门癌患者，经此法共介入灌注１４６次，最多５次，最少１次，胃部病灶ＣＲ＋ＰＲ占６１．５％，生存最长４１个月，最短４个月，中位生存期９．５个月，半年生存率为７６．９％，１年生存率为３０．８％。结论采用肿瘤供血动脉进行区域性灌注生物制剂及化疗药物，对于失去手术机会的晚期贲门癌病人。
Objeative To observe the therapeutic effect of chemotherpy drugs and LAK/IL-2 by intrartery in the treatment of late stage cardia cancer.Method Percutaneous left gastric artery interventional therapy was given to the patients once every 3-4 weeks,with LAK cells (of healthy person)1×10 9/100ml,IL 2 30,0000u,and chemotherapy drugs (epiadriamycin 30 mg, carboplatin 300mg,vindesine 4 mg,or 5 Fu 1000 mg)intrarterial perfusion.Two cycles was one therapeutic course.Result 78 patients with late stage cardia cancer were diagnosed by pathology.The interventional therapy was given totally 146 times, the most 5 times,the least 1 time. Lesions of stomach achieved CR+PR accounted for 61.5%, medium survival time was 9.5 months(the longest 41 months,the shortest 4 months),6 months survival rate was 76.9%,1 year survival rate was 30.8%.Conclusion For patisnts of late stage cardia cancer who had lost the chance of operation,intrarterial intervention therapy with biological preparations and chemotherapy drugs perfusion would be a preferable,selectabale effective way of treatment.
关键词
晚期
贲门癌
LAK
药物疗法
白细胞介素2
胃肿瘤
Late stage cardia cancer Intrarterial perfusion Chemotherapy drug LAK/IL 2
