摘要
目的探讨胰腺癌甾体激素受体状态及其生物学特征。方法采用Ｓ－Ｐ免疫组化方法对５０例胰腺导管腺癌雌激素受体（ＥＲ）、孕激素受体（ＰＲ）进行检测。结果胰腺导管腺癌ＥＲ阳性率５０．０％（２５／５０）ＰＲ阳性率４６．０％（２３／５０）。ＥＲ、ＰＲ状态与癌组织的分化程度密切相关（Ｐ＜０．０１），癌组织分化越好，ＥＲ、ＰＲ水平越高。无转移的胰腺癌ＥＲ水平高于有转移灶者（Ｐ＜０．０５）。ＥＲ、ＰＲ水平与性别、年龄、ＴＭＭ分期均无明显关系（Ｐ＞０．０５）。结论胰腺癌组织内存在ＥＲ、ＰＲ。
Objective To explore the state of the steriod hormone receptors of the pancreas and its biological behaviour.Methods The estrogen and progesterone receptors in 50 cases of ductal carcinomas of the pancreas were detected by immunohistochemical SP method.Results The ER and PR positive rates were 50.0% and 46.0%.ER and PR levels were significantly correlated with differentiation of the cancer(P<0.01).The level of ER in patients of metastasis was lower than that of no metastasis(P<0.05).The ER and PR Level was associated with sex,age as well as TNM stage(P>0.05).Conclusions There exist ER and PR in pancreatic cancer.The level of the ER and PR reflects the biological behaviour of the disease.
关键词
胰腺肿瘤
雌激素受体
孕激素受体
免疫组织化学
Pancreatic neoplasmas Estrogen receptor Progesterone receptor Immunhistochemistry.
