摘要
对１２６例血液病患者ＨＣＶ和ＨＢＶ感染及其病毒复制进行了研究。结果：①１２６例患者中ＨＣＶ抗体阳性８例（６．４％），大约比献血员感染率高１０倍（Ｐ＜０．０１）；在抗体阳性者中有７例ＨＣＶ－ＲＮＡ阳性（８７．５％）。②所测患者中ＨＢＶ五项标志物单项或多项阳性２６例（２０．６％），其中ＨＢＶ－ＤＮＡ阳性１２例（４６．２％）；在８例ＨＣＶ感染者中有３例与ＨＢＶ重叠感染（３７．５％），５例有既往输血史（６２．５％），４例ＡＬＴ异常（５０．０％）。研究表明，血液病患者中存在着较高的ＨＣＶ和ＨＢＶ感染以及病毒复制，应采取有效措施控制肝炎病毒的传播。
The prevalences and replications of hepatitis C virus (HCV) and hepatitis B virus infections were investigated in patients with haematological diseases. The results showed that the incidence of anti-HCV was 6.4% (8/126) in patients with haematology dieases and ten times as high as that of blood donors (P<0.01). The incidence of HCV -RNA was 87.5% (7/8) in 8 patients with HCV antibody positive. The incidence of one or multiple HBV markers ( HBsAg, HBsAb, HBeAg, HBeAb and HBcAb) was 20.6% (26/126) in these patients and the positive rate of HBV-DNA was 46.2% (12/26) in HBV marker positive patients. Of patients with HCV infection, three patients ( 37. 5%) was coinfected with HBV; five patients (62.5%) had the history of blood transfusion; and four (50.0%), abnormal activity of serum ALT. The present data suggest that there are higher infections of HCV or/and HBV and their replication in patients with haematological diseases and attention should be paid to control transmission of hepatitis viruses with effective measures.
出处
《南通医学院学报》
1998年第4期436-437,共2页
ACTA Academiae Medicinae Nantong
