摘要
目的:观察对以泊路沙姆为助溶剂的脉络宁新注射液(P-脉络宁)对缺血性脑损伤的保护作用.方法:测定P-脉络宁注射液对不同缺血模型及血液流变学的作用.结果:脉络宁注射液能明显降低家兔的全血比粘度;血浆比粘度及红细胞比容;并能明显缩小小鼠大脑中动脉阻断(MCAO)后引起的脑梗死范围,降低毛细血管通透性、脑含水量和脑指数.结论:P-脉络宁可以通过改善上述各指标,有效地保护缺血引起的脑损伤;而助溶剂则无此脑保护作用.
AIM:To investigate the protective effects against cerebral ischemia of a new mailuoning injection prepared with poloxamer. METHODS:The effect of mailuoning on he-morrheological factors and different cerebral ischemic models was measured. RESULTS: Whole blood viscosity, plasma viscosity, and hematocrit were significantly reduced after administration of this injection in rabbits. The infarct size that was induced by cerebral mid-dle artery occlusion (MCAO), the water containing, the brain index and the permeability of capillary after the occlusion of bi-lateral carotid in mice were also greatly decreased. CON-CLUSION: The new mailuoling injection shows protective effects to against cerebral ischemia by improving these factors, while the poloxamer alone do not produce these protective ef-fects.
出处
《中国临床药学杂志》
CAS
1998年第6期290-213,共1页
Chinese Journal of Clinical Pharmacy
关键词
脉络宁
血液流变学
血管通透性
脑缺血
mailuoning
hemorrheology
cerebral infarction
braimwater containing
brain index
capillary permeability
